Two main ALDH enzymes metabolize the acetaldehyde produced during ethanol oxidation (see Table 3) (Crabb et al. 2004; Hurley et al. 2002): ALDH1, which is found in the fluid filling the cells (i.e., the cytosol) and is encoded by the ALDH1A1 gene, and ALDH2, which is found in the mitochondria and is encoded by the ALDH2 gene.

2021年8月1日 · In this study, we asked if spinal ALDH2 regulates ethanol metabolites and the ethanol-induced analgesic effect in mice. We tested this hypothesis by performing various in vitro and in vivo experiments in cell-type-specific ALDH2-deficient mice. We also explored the possible mechanism underlying astrocytic ALDH2 control of ethanol analgesia.

2021年3月22日 · Jin et al. show that astrocytic ALDH2 metabolizes ethanol in the brain, thereby attributing behavioural effects of alcohol to metabolites produced in the brain rather than the liver.

2013年5月21日 · Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic...

Ethanol metabolites such as acetate, thought to be primarily the result of ethanol breakdown by hepatic aldehyde dehydrogenase 2 (ALDH2), contribute to alcohol's behavioural effects and alcoholism. Here, we show that ALDH2 is expressed in astrocytes in the mouse cerebellum and that ethanol metabolism by astrocytic ALDH2 mediates behavioural ...

2022年6月13日 · 该研究启示 星形细胞aldh2可能是治疗酒精中毒的有用靶点，可通过调控星形胶质细胞aldh2表达，以助力解酒、戒酒，以及酒精诱发的脑损伤、退化的预防与治疗。同时，为研究醉酒行为的相关机制开辟了新方向，还可为老年痴呆（阿尔兹海默氏综合征）等神经 ...

2018年10月12日 · ALDH2 deficiency inhibits ethanol protection by producing 4-HNE-SIRT1 adducts. 4-HNE-SIRT1 blocks the translocation of SIRT1 from the cytoplasm to the nucleus. Cytoplasmic SIRT1 promotes endothelial senescence by increasing p53 acetylation. Aldehyde dehydrogenase 2 (ALDH2) plays essential roles in drinking-associated diseases or effects.

2024年6月20日 · Alcohol dehydrogenase (ADH) is responsible for transforming ethanol into a toxic intermediate byproduct, acetaldehyde (AcH). Then, aldehyde dehydrogenase ALDH, mainly ALDH2, converts AcH to...

1997年5月15日 · Mitochondrial aldehyde dehydrogenase (ALDH2) is a tetrameric enzyme that catalyzes the oxidation of acetaldehyde to acetate during ethanol metabolism. Approximately 50% of the Asian population have an inactive variant of ALDH2.

Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Subpopulations of Asians and Native Americans show polymorphism with loss-of-function mutations in ALDH2. We evaluated the effect of ALDH2 deficiency on EtOH-induced disruption of intestinal epithelial tight junctions and adherens junctions, gut barrier dysfunction, and liver ...