Ubiquitination in the ERAD Process - PubMed
2020年7月28日 · We present the various ERAD components involved in the ubiquitination process including the different E2 conjugating enzymes, E3 ligases, and E4 factors. The …
Quantitative proteomics reveals the function of unconventional ...
2009年4月3日 · Ubc6 primarily synthesizes K11-linked chains, and K11 linkages function in the ERAD pathway. Thus, unconventional polyubiquitin chains are critical for ubiquitin-proteasome …
Emerging functions of branched ubiquitin chains | Cell …
2021年1月26日 · UBR5 collaborates with an unknown K11-specific E3 to form branched K11/K48 chains of a different architecture on a pathological mutant version of the Huntingtin protein …
Diversity of Polyubiquitin Chains - ScienceDirect
2009年4月21日 · An E3 ligase responsible for K11 polyubiquitination appears to be Doa10, which is known to function with Ubc6 in the ERAD pathway. The study by Xu et al. highlights the …
Quantitative Proteomics Reveals the Function of Unconventional ...
2009年4月3日 · Ubc6 primarily synthesizes K11-linked chains, and K11 linkages function in the ERAD pathway. Thus, unconventional polyubiquitin chains are critical for ubiquitin-proteasome …
Science | 由Hrd1复合体介导的内质网相关蛋白质降解的机制 - 知乎
当新合成的蛋白质发生错误折叠时，它最终会被从内质网中逆向转运到细胞质，随后被多 泛素化 并降解，这是一种称为内质网相关蛋白降解（erad）的途径。erad减轻了蛋白质错误折叠引起 …
Ubiquitination in the ERAD Process - PMC - PubMed Central (PMC)
The resulting K48-linked and K11-linked ubiquitin chains do not only represent a signal for degradation by the proteasome but are also recognized by the AAA+ ATPase Cdc48 and get …
Ubc6 primarily synthesizes K11-linked chains, and K11 linkages function in the ERAD pathway. Thus, unconventional polyubiquitin chains are critical for ubiquitin-proteasome system …
定量蛋白质组学揭示了非常规泛素链在蛋白酶体降解中的作用 …
Ubc6 主要合成 K11 连接链，K11 连接在 ERAD 通路中起作用。 因此，非常规多聚泛素链对于泛素-蛋白酶体系统功能至关重要。 Quantitative proteomics reveals the function of …
ERAD过程中的泛素化,International Journal of Molecular Sciences
我们介绍了泛素化过程中涉及的各种erad组件，包括不同的e2缀合酶，e3连接酶和e4因子。 产生的K48连接和K11连接的泛素链不仅代表蛋白酶体降解的信号，而且还被AAA + ATPase …