Eplerenone, sold under the brand name Inspra, is an aldosterone antagonist type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly …

2023年5月1日 · Review interprofessional team strategies for improving care coordination and communication to support optimal medication outcomes for patients prescribed eplerenone. …

Eplerenone, Food and Drug Administration (FDA) approved in 2002, is an acceptable alternative to spironolactone due to its sparing androgenic effects. In two big pivotal trials in heart failure …

2017年8月15日 · The present paper deals with synthesis, physicochemical characterization and comprehensive structural elucidation and confirmation of the process-related eplerenone …

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition …

2018年9月10日 · Two novel high-performance liquid chromatography methods for the determination of process-related impurities of eplerenone drug substance and the designated …

2021年10月13日 · Eplerenone is metabolized in the liver by the cytochrome P450 system (CYP 3A4) and hepatic reactions may be generated by intermediates in its metabolism. The mild …

治疗高血压和其他心血管疾病的新型药物。 用于治疗高血压。 中文名:依普利酮,英文名:eplerenone,CAS:107724-20-9,化学式:C24H30O6,分子量:414.49,密度:1.31±0.1 g/cm3 …

2004年2月15日 · Synopsis: Eplerenone, a potassium-sparing diuretic similar to spironolactone, selectively blocks aldosterone to lower blood pressure. However, its safety profile is improved …

6 天之前 · 依普利酮选择性作用于醛甾酮受体，对盐皮质激素受体具高度选择性，而对雄激素和孕酮受体作用较小，对盐皮质激素的亲和力是螺内酯的 15~20倍，而对雄激素和孕激素受体的亲 …