Enterovirus 71 vaccines To date three vaccines against EV71 have been licensed in China, all using C4 genogroup strains. The efficacy of these three vaccines after two doses immunization ranges from 90.0% to 97.4% after one year of surveillance to 95.1% after two-year follow-up.

Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus ...

2017年6月1日 · Development of vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks. Here, we summarize EV71 infection and development of vaccines, focusing on current scientific and clinical progress.

2024年10月15日 · This study aimed to evaluate the safety of the enterovirus 71 (EV71) vaccine administered alone or concurrently with other vaccines in infants 6-11 months. A total of 3,769 EV71 vaccine doses were administered to children in the active surveillance area, of which 1,909 were administered concurrently with other vaccines and 1,860 doses were ...

EV71 CNS involvement may be associated with neurological sequelae, delayed neurodevelopment and reduced cognitive functioning. Since poliovirus was nearly eradicated by vaccination, EV71 is now considered as one of the top candidates for new vaccine development against human enteroviruses.

2014年2月27日 · The EV71 vaccine provided protection against EV71-associated hand, foot, and mouth disease or herpangina in infants and young children.

The enterovirus 71 (EV71) vaccine produced by Wuhan Institute of Biological Products Co., Ltd. (WIBP) (B-EV71) has been given to children aged 6-35 months, and it has shown good safety, immunogenicity and efficacy.

2014年2月27日 · Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease in children and may be fatal. A vaccine against EV71 is needed. We conducted a randomized, double-blind,...

2024年4月23日 · There is no vaccine available in the United States to prevent EV-A71. First identified in the United States in 1969, enterovirus A71 (EV-A71) is one of more than 100 non-polio enteroviruses. Worldwide, EV-A71 is a common cause of hand, foot, and mouth disease (HFMD) in infants and young children.

2022年4月30日 · Children are susceptible to severe or fatal enterovirus 71 (EV71) infections. We aimed to evaluate the efficacy, safety, and immunogenicity of EV71vac, an aluminium phosphate-adjuvanted inactivated EV71 vaccine in children aged 2–71 months.