Familial AD Mutations, β-CTF, Spell Trouble for Endosomes
2019年8月17日 · Endosome enlargement is an early cytopathology in AD, and multiple genes that confer increased risk for sporadic AD (sAD) are in loci attributed to endocytosis and vesicular …
Without SORL1, Endosomes Swell in Neurons but not Microglia
2020年6月2日 · Adding the discontinued BACE inhibitor LY2886721 did not reverse these endosome changes, even though it reduced production of sAPPβ, APP β-C-terminal …
When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster
2023年2月2日 · Several groups had previously demonstrated that the overexpression of full-length SorL1 decreased APP trafficking in the secretory pathway, while also assisting APP in …
ALS/FTD Genes Converge on Endolysosomal System, Stoking TDP …
2022年10月18日 · Crucially, cells expressing poly-GA that had endosome abnormalities also shunted TDP-43 from the nucleus into cytoplasmic inclusions, which are a hallmark pathology …
APP in Pieces: βCTF implicated in Endosome Dysfunction
2010年1月26日 · Conversely, overexpressing APP or the βCTF in normal human fibroblasts induced endosome pathology. Jiang did not see the effect after transfecting a β-cleavage …
Endosomal Dysfunction Induced by Directly Overactivating Rab5 ...
2021年1月13日 · Aβ’s involvement in endosome changes was often excluded by lack of protection against such changes by γ-secretase inhibition, which blocks production of Aβ but …
Biomarkers of Errant Endosome Spotted in Cerebrospinal Fluid
2020年12月5日 · Addressing more broadly how the retromer fits into the AD pathology continuum, Small proposes that dysfunctional endosome recycling lies upstream of all four AD …
Going It Alone—APP, BACE1 Take Distinct Routes to Endosome
2011年8月17日 · APP (red) and BACE1 (pink) follow distinct routes to the early endosome. Blocking specific points along the ARF6-mediated BACE internalization pathway has opposing …
Accumulation of APP C-terminal fragments causes ... - ALZFORUM
2024年4月27日 · This paper by Bretou et al. is a tour de force with diverse and elegant methods, and provides numerous novel insights, such as on the importance of APP CTFs at membrane …
Alzheimer's-related endosome dysfunction in Down syndrome is …
2010年1月26日 · News: APP in Pieces: βCTF implicated in Endosome Dysfunction It is established that overexpression of APP, such as in Down syndrome, leads to endosome …