Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. [5][6] ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice. The human engulfment and cell motility protein 1, ELMO1, is 720 residues in length. The protein contains the following three domains:

Mar 28, 2025 · ELMO1 (Engulfment And Cell Motility 1) is a Protein Coding gene. Diseases associated with ELMO1 include Diaphanospondylodysostosis and Immunodeficiency 40. Among its related pathways are Regulation of actin dynamics for …

该基因和胞质分裂因子 1 的表达增加可能促进胶质瘤细胞侵袭，该基因的单核苷酸多态性可能与糖尿病肾病有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 8 月] This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration.

Jun 6, 2022 · ELMO1, through binding with Dock180 and activation of the Rac1 signaling pathway, plays a significant role in cellular shaping and motility. Rac-mediated actin cytoskeletal rearrangement is essential for bacterial phagocytosis, but also plays a crucial role in processes such as cancer cell invasion and metastasis.

ELMO1 is expressed in rheumatoid arthritis synovium, promotes cell migration and invasion, and regulates Rac1 activity, thereby mediating rheumatoid arthritis pathogenicity. Src-mediated Y724 phosphorylation in ELMO1 plays a critical role for cell spreading via activation of Rac1, leading to promotion of cell migration.

Aug 17, 2021 · Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in osteoclasts. We note that ELMO1 SNPs associate with bone abnormalities in humans, and that ELMO1 deletion...

Jan 14, 2019 · We noted single-nucleotide polymorphisms (SNPs) in the apoptotic cell–engulfment genes ELMO1, DOCK2, and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganization...

Nov 1, 2024 · Engulfment and cell motility 1 (ELMO1) plays an important function in cellular dynamics. In view of this, the aim of this study was to explore the expression of ELMO1 in PBC, its effects on the proliferation, migration, and secretion of inflammatory factors by the mainly regulated immune cells and the specific molecular mechanisms behind it.

Mar 25, 2025 · Engulfment and cell motility protein 1 (Elmo1) forms a complex with Dedicator of cytokinesis (Dock) 1–5 and promotes GTP-loading of Rac1, the major agent of cell movement.

In this review, we provide an updated and comprehensive summary of the roles of ELMO1 in infection, inflammatory diseases and cancer. We highlight the possible mechanisms regulated by ELMO1 that are relevant for cancer development and progression and provide insight into the possible use of ELMO1 as …