2025年3月28日 · ELMO1 (Engulfment And Cell Motility 1) is a Protein Coding gene. Diseases associated with ELMO1 include Diaphanospondylodysostosis and Immunodeficiency 40. Among its related pathways are Regulation of actin dynamics for …

该基因和胞质分裂因子 1 的表达增加可能促进胶质瘤细胞侵袭，该基因的单核苷酸多态性可能与糖尿病肾病有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 8 月] This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration.

Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. [5] [6] ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice.

背景 吞噬和细胞运动蛋白 1 (ELMO1) 是先天免疫的关键蛋白，因为它是清除凋亡细胞和病原菌以及控制炎症反应所必需的。ELMO1 通过与 Dock180 结合并激活 Rac1 信号通路，在细胞成形和运动中发挥重要作用。

2022年6月6日 · ELMO1, through binding with Dock180 and activation of the Rac1 signaling pathway, plays a significant role in cellular shaping and motility. Rac-mediated actin cytoskeletal rearrangement is essential for bacterial phagocytosis, but also plays a crucial role in processes such as cancer cell invasion and metastasis.

我们前期采用双向电泳-质谱分析发现肝癌组织中Elmo1表达增加；Elmo1高表达能够增强肝癌细胞侵袭能力且伴有明显的EMT现象（E-cadherin下调，Vimentin上调），PI3K通路抑制剂可逆转该效应。

研究人员试图确定吞噬和细胞运动蛋白1 [elmo1] 在体外和体内伤口愈合中的作用，并研究其潜在的治疗效能。 背景和目标 粘膜愈合是IBD治疗的目标，可以导致 炎症性肠病 [IBD]更长的 临床 缓解。

ELMO1 is expressed in rheumatoid arthritis synovium, promotes cell migration and invasion, and regulates Rac1 activity, thereby mediating rheumatoid arthritis pathogenicity. Src-mediated Y724 phosphorylation in ELMO1 plays a critical role for cell spreading via activation of Rac1, leading to promotion of cell migration.

2021年8月17日 · Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in osteoclasts. We note that ELMO1 SNPs associate with bone abnormalities in humans, and that ELMO1 deletion...

2019年1月14日 · We noted single-nucleotide polymorphisms (SNPs) in the apoptotic cell–engulfment genes ELMO1, DOCK2, and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganization...