2023年5月29日 · Endocardial fibroelastosis (EFE) is primarily a disease of infants and children, but can rarely present in adulthood as well. In 1943, the endocardial fibroelastosis term was coined by Weinberg et al. in children who presented with unexplained heart failure previously known as 'fetal endocarditis.'

2025年2月12日 · Endocardial fibroelastosis (EFE) is a rare cardiac condition which is classically described in the pediatric population (typically first two years). It is one of the causes in infants of unexplained heart failure. The condition results from increasing amounts of fibrous and elastic tissue affecting the endocardium as well as the subendocardium.

EFE is characterized by a thickening of the innermost lining of the heart chambers (the endocardium) due to an increase in the amount of supporting connective tissue and elastic fibres. It is an uncommon cause of unexplained heart failure in infants and children, and is one component of HEC syndrome.

Though fetal endocardial fibroelastosis (EFE) has been reported in the past three decades, the classical echocardiographic features of EFE following maternal organophosphorus ingestion at 20 weeks of gestation is reported for the first time in the literature.

2008年1月3日 · Echocardiography findings suggestive of EFE include increased endocardial echo-brightness and a globular shape of the LV . However, previous reports have revealed a weak association between the echocardiographic appearance of echo-brightness of the myocardium and the histologic evidence of EFE at autopsy [ 2 ].

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2015年1月13日 · By utilizing a novel EFE model of heterotopic transplantation of hearts from newborn reporter mice and by analyzing human EFE tissue, we demonstrate for the first time that fibrogenic cells within EFE tissue originate from endocardial endothelial cells via aberrant endothelial to mesenchymal transition.

Our study suggests that 2-dimensional echocardiographic determination of echo-brightness cannot reliably predict the presence of EFE. With a specificity of 77%, 23% of patients thought to have EFE on echocardiography will not have it on histologic examination.

Background: There are few reports describing the features of maternal anti-SSA antibody-associated congenital complete heart block (CCHB) patients developing endocardial fibroelastosis (EFE). The aim of this study was to describe the clinical features and the outcome of patients with CCHB, with or without EFE.

Endocardial Fibroelastosis (EFE) is characterized by a thick layer of cellular fibro-elastic tissue caused by endocardial endothelial cells undergoing a process called endothelial-to-mesenchymal transition.