Pertussis toxin (PTX) is a required co-adjuvant for experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin antigen. However, PTX’s effects on EAE induced …

Th1 and Th17 cells may contribute to the initiation and progression of EAE, whereas Th2-type cytokines IL-4 and IL-10 may dampen autoimmune responses in EAE. CD4 + T cells isolated …

1 小时前 · The published single cell dataset of isolated CD45 + cells from various CNS compartments in mouse EAE (GSE118948) was used to validate the appearance of senescent …

The most striking effect of altered CD45 isoform expression is on the development of EAE. Both CD45 RABC/+ and CD45 RO/+ mice showed more rapid onset and increased severity of …

2019年2月12日 · To determine whether OT-II memory-like T H 17 cells contribute to the development of EAE, we adoptively transferred MOG–TCR-transgenic (2D2) naive CD45.1 …

It was shown that macrophages/microglia express CD4 in the CNS during EAE, and it was suggested that CD4 + microglia, defined as CD11b + CD45 low/intermediate cells, contributed …

2018年3月23日 · In both multiple sclerosis and its model experimental autoimmune encephalomyelitis (EAE), the extent of resident microglia activation and infiltration of monocyte …

2001年4月4日 · In a model of experimental autoimmune encephalomyelitis (EAE), evidence is presented that CD40–CD154 interactions within the central nervous system (CNS) are critical …

In EAE animals (B–M) strong changes in distribution and morphology of CD45+ cells were found during the evolution of the disease. During the inductive phase (B– D) from score 0.5, but...

2009年4月30日 · Flow cytometry analysis showed that EAE induced CD4 expression in macrophages (CD11b+/CD45 (high)) and microglia (in both CD11b+/CD45 (intermediate) and …