实验性自身免疫性脑脊髓炎（experimental autoimmune encephalomyelitis，EAE）是一种以特异性致敏的CD4+T细胞介导为主的，以中枢神经系统内小血管周围出现单个核细胞浸润及髓鞘脱失为特征的自身免疫性疾病，其病…

2019年8月7日 · Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +, CD8 + and γδ + T cells in the blood...

2019年2月12日 · From our study, we demonstrate an important role for antigen non-related bystander CD4 + T cells in EAE pathogenesis, which are activated by IL-1β together with IL-23. These cells are the major...

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the central nervous system (CNS) often used as a model for the early inflammatory stages of multiple sclerosis and also as a model of organ-specific autoimmune disease.This protocol describes the induction of passive EAE in …

2014年10月7日 · Here we show that nicotinamide adenine dinucleotide (NAD +) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ +...

2017年7月5日 · Here we describe protocols for passive transfer model of EAE using freshly isolated (MOG)-specific CD4 + T cells or periodically restimulated MOG-specific CD4 + T cell lines, which are suitable for tracking pathogenic CD4 + T cells in vivo, particularly in the CNS ( Ogura et al., 2008 ; Arima et al., 2012 and 2015b).

2018年6月27日 · Results: Four infusions of the tNPs durably ameliorated EAE with a marked reduction of clinical score, neuroinflammation and demyelination. They were distributed in secondary lymphoid tissues, various organs and brain after intravenous injection, with retention over 36 h, and made contacts with CD4 + and CD8 + T cells.

2019年8月22日 · 美国斯坦福大学医学院Mark M. Davis课题组发现了实验性自身免疫性脑脊髓炎（EAE）中T细胞反应的对抗机制，相关论文发表在2019年8月22日出版的《自然 ...

在这里，我们描述了使用MOG特异性CD4 + T细胞的被动转移EAE模型的详细方案，其适合于在体内跟踪自体CD4 + sup + T细胞。虽然已经报告了EAE协议（Racke，2001），但我们特别关注被动传输EAE模型，并详细描述了这些方法。

In multiple sclerosis (MS), myelin antigen-autoreactive CD4 + T cells and CD8 + T cells target and destroy myelin sheath on the nerve cells, thereby leading to substantial neuroinflammation, demyelination, axonal damage and progressive neurologic dysfunction, 1 and slowly causing permanent physical disability. 2, 3 Experimental autoimmune ...