2025年3月30日 · ETV4 (ETS Variant Transcription Factor 4) is a Protein Coding gene. Diseases associated with ETV4 include Skeletal Ewing Sarcoma and Hemorrhage, Intracerebral. Among its related pathways are MAPK family signaling cascades and Autodegradation of …

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors. [5][6][7] Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma.

2024年5月3日 · Here we found that a well-known oncogene, ETS variant transcription factor 4 (ETV4), serves as a molecular transducer that links mechanical microenvironments and gene expression. In a growing...

2024年10月12日 · 研究结果表明， ETV4 P433L突变影响肿瘤的干细胞特性和通过Wnt/β-catenin信号通路的迁移， 为MPLC治疗提供了新的分子靶点。 关于多发性原发性肺癌. 多发性原发性肺癌（MPLC）定义为同一患者同时或连续发生2种或多种原发性肺癌。 大约15%的肺癌患者表现出2个或多个病灶的发展，MPLC是常见的表现。 MPLC或多发磨玻璃/鳞状（GG/L）结节具有独特的遗传特征，值得被视为一种不同于肺癌的独立疾病。 团队发现，一级亲属的发病率非常 …

ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification. An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression. ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of keratinocyte differentiation and positive regulation of …

2025年2月8日 · Title: Identification and characterization of novel ETV4 splice variants in prostate cancer. ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.

E26 transformation-specific (ETS) variant 4 (ETV4) is an important transcription factor that belongs to the ETS transcription factor family and is essential for much cellular physiology. Recent evidence has revealed that ETV4 is aberrantly expressed in many types of tumors, and its overexpression is related to poor prognosis of cancer patients.

2025年2月27日 · ETS variant transcription factor 4 (ETV4), an important transcription factor, plays a key role in various cancers. However, the role of ETV4 in HNSC remains unclear. This study aimed to explore the potential prognostic value and oncogenic effects of ETV4 in HNSC.

他们将目光聚焦于 ETS 变异转录因子 4（ETS variant transcription factor 4，ETV4），致力于探究其在 HNSC 中的潜在预后价值和致癌作用。 经过一系列深入研究，研究人员发现 ETV4 在 HNSC 中显著过表达，并且与患者的临床病理特征和预后密切相关。 这一发现意义重大，它表明 ETV4 有望成为 HNSC 预后的生物标志物和免疫治疗的新靶点，为 HNSC 的诊断和治疗开辟了新的方向。 该研究成果发表在《Scientific Reports》上。 为开展此项研究，研究人员运用了多种关键技术 …