ERAP1 - Wikipedia
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that in humans is encoded by the ERAP1 gene. This M1 zinc aminopeptidase is involved in the antigen processing and …
内质网氨肽酶 1（ERAP1）基因 | MCE - MCE-生物活性分子大师
内质网氨肽酶 1： 该基因编码的蛋白质是一种氨肽酶，参与修剪 HLA I 类结合前体，以便它们可以呈现在 MHC I 类分子上。编码的蛋白质作为单体或与 ERAP2 形成异二聚体。这种蛋白质还 …
ERAP1 Gene - GeneCards | ERAP1 Protein | ERAP1 Antibody
6 天之前 · ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) is a Protein Coding gene. Diseases associated with ERAP1 include Peeling Skin-Leukonuchia-Acral Punctate Keratoses …
首款ERAP1抑制剂进入临床开发阶段 - 健康界
2023年3月30日 · erap1在抗原加工和修饰n端延伸肽到mhci类分子表达的最佳大小中起主要作用。 研究证明ERAP1可以形成二聚体复合物，更有效地切割残基。 除了ERAP1的主要酶促功能及 …
ERAP1: a potential therapeutic target for a myriad of diseases
Introduction: Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key regulator of the peptide repertoire displayed by Major Histocompatibility Complex I (MHC I) to circulating CD8 + T cells …
ERAP1 endoplasmic reticulum aminopeptidase 1 [ (human)]
2025年2月8日 · ERAP1 as an emerging therapeutic target for medulloblastoma. A proposed HLA-B*27 screening method for ankylosing spondylitis detection based on tag-single nucleotide …
ERAP1 is a critical regulator of inflammasome-mediated …
2022年3月4日 · Here, we investigated the role of ERAP1 in suppressing inflammasome pathways and their dependence on ER stress responses. Using bone marrow-derived macrophages …
The Role of Aminopeptidase ERAP1 in Human Pathology—A Review
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for …
Structural basis for antigenic peptide precursor processing by the ...
2011年4月10日 · ERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1 has unique substrate preferences, trimming long peptides but sparing shorter …
ERAP1 gene - MedlinePlus
The ERAP1 gene provides instructions for making a protein called endoplasmic reticulum aminopeptidase 1. As its name suggests, this protein is active in a cellular structure called the …