This enzyme, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding diols. A different region of this protein also has lipid-phosphate phosphatase activity. Mutations in the EPHX2 gene have been associated with familial hypercholesterolemia. [5]

2025年3月30日 · EPHX2 (Epoxide Hydrolase 2) is a Protein Coding gene. Diseases associated with EPHX2 include Hypercholesterolemia, Familial, 1 and Familial Hypercholesterolemia. Among its related pathways are Biosynthesis of specialized proresolving mediators (SPMs) …

2023年7月5日 · 可溶性环氧化物水解酶（sEH，EPHX2基因编码） 是一种环氧脂肪酸代谢的关键酶，广泛分布于肝、肾、脑等众多器官中。 大脑不能合成不饱和脂肪酸 ...

2016年10月3日 · Gene target information for EPHX2 - epoxide hydrolase 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Soluble epoxide hydrolase 2 (EPHX2) is an enzyme promoting increased cellular apoptosis through induction of oxidative stress (OS) and inflammation. The gene which encodes soluble EPHX2 might be implicated in the pathogenesis and development of OS and atherosclerosis.

2008年4月28日 · We performed invasive cardiac hemodynamic measurements in F 2 crosses between spontaneously hypertensive heart failure (SHHF) rats and reference strains. We combined linkage analyses with...

2020年12月22日 · The EPHX2 gene, which is located on chromosome 8 and consists of 19 coding exons, encodes a protein of 555 residues. The EPHX2 protein also known as soluble epoxide hydrolase (sEH) is highly conserved throughout evolution.

该基因编码环氧化物水解酶家族的一个成员。 在胞质溶胶和过氧化物酶体中发现的蛋白质与特定的环氧化物结合并将其转化为相应的二氢二醇。 该基因的突变与家族性高胆固醇血症有关。 已经描述了选择性剪接的转录物变体。 [RefSeq 提供，2012 年 2 月] This gene encodes a member of the Epoxide Hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols.

2025年2月8日 · Ephx2 deficiency has significant contribution in coordination of ambulatory movements and working spatial memory in the mouse. We conclude that type 1 diabetes mellitus upregulates soluble epoxide hydrolase mRNA and decreases concentrations of neuroprotective epoxyeicosatrienoic acids within the brain, leading to worse stroke outcome.

2022年5月15日 · Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites. EPHX2 is highly polymorphic, and genetic polymorphisms in EPHX2 have been linked to various types of CVDs, such as coronary heart disease, essential hypertension, and atrial fibrillation recurrence.