2024年7月15日 · We demonstrate that Zeb1 increases the ratio of phospholipids containing pro-ferroptotic polyunsaturated fatty acids over cyto-protective monounsaturated fatty acids by …

2020年2月24日 · Our study demonstrates a novel example of an activator role of ZEB1 for the epigenetic landscape in colorectal tumor cells. Activation of a partial epithelial–mesenchymal …

在胰腺癌中，E-cadherin的下调是通过ZEB1发生的，ZEB1将HDAC1和HDAC2招募到CDH1启动子上以沉默其表达。 此外，E-cadherin的表达受SMAR1调控，SMAR1与HDAC1形成复合物， …

Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

2020年2月3日 · Increasing evidence suggests that ZEB1 stimulates tumor cells with mesenchymal traits and promotes multidrug resistance, proliferation, and metastasis, …

2010年4月26日 · In this study, we show that ZEB1 interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CtBP, its traditional co …

2022年12月13日 · Using multi-omics, inhibitors, and high-content microscopy, we discover a chemoresistant ZEB1-high-expressing sub-population (ZEB1 hi) with co-rewired cell-cycle …

We demonstrate that Zeb1 increases the ratio of phospholipids containing pro-ferroptotic polyunsaturated fatty acids over cyto-protective monounsaturated fatty acids by modulating …

2020年3月18日 · Zinc finger E-box binding homeobox 1 (ZEB1) is a prime element of a network of transcription factors controlling EMT and has been identified as an important molecule in the …

2020年7月21日 · We identified ZEB 1 as a novel interactor of the AP ‐1 factors FOSL 1 and JUN and show that, together with the Hippo pathway effector YAP, they form a transactivation …