In this review, we summarise the role of CXCR4 and CXCL12 in tumour growth, metastasis, angiogenesis, and cancer cell-microenvironment interaction. Furthermore, we discuss the …

2024年9月5日 · Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is involved …

AMD3100 was shown to specifically antagonize CXCR4, and thus to block the entry of the T-lymphotropic HIV strains (6–8). AMD3100 appears to be a highly specific inhibitor of CXCR4 ( …

The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, …

2024年12月19日 · The new peptide CXCR4 inhibitor, R54 impaired CXCR4 activity reducing cell growth, migration and signalling in human ovarian cancer cells. Moreover, CXCL12 promoted …

2024年12月5日 · We identified a novel heptapeptide that fully replicates the pharmacological profile of the parent peptide on CXCR4, including its potency, selectivity, and antagonistic …

Recently, CXCR4 has been reported to play an important role in cell survival, proliferation, migration, as well as metastasis of several cancers including breast cancer. This review is …

CXCR4 is a chemokine receptor that mediates invasion and metastasis. CXCR4 expression is transcriptionally regulated in cancer cells and is associated with aggressive phenotypes of …

Immunofluorescent imaging and flow cytometry were performed to examine the expression of CXCR4 in the EJ and EJ-M3 cell lines. A highly specific CXCR4 antagonist, AMD3100, was …

C-X-C chemokine receptor type 4 (CXCR4)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白表达，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助 …