2025年3月30日 · EHD2 (EH Domain Containing 2) is a Protein Coding gene. Diseases associated with EHD2 include Epilepsy, Idiopathic Generalized 2 and Distal Myopathy. Among its related pathways are Angiopoietin-like protein 8 regulatory pathway and Response to …

EH domain-containing protein 2 (EHD2) is a member of the EHD protein family and is mainly located in the plasma membrane, but can also be found in the cytoplasm and endosomes. EHD2 is also a nuclear-cytoplasmic shuttle protein. After entering the cell nuclear, EHD2 acts as a corepressor of transcrip …

EH-domain containing 2, also known as EHD2, is a human gene [5] belonging to the EHD protein family.

2024年4月13日 · 含EH结构域的蛋白2（EHD2）是EHD蛋白家族的成员，主要位于质膜中，但也存在于细胞质和内体中。 EHD2 也是一种核质穿梭蛋白。 进入细胞核后，EHD2作为转录辅阻遏物抑制基因转录。 EHD2 调节一系列生物过程。 作为内吞转运的关键调节因子，EHD2 参与内体小管和囊泡的形成和维持，这对于蛋白质和其他物质的细胞内转运至关重要。 EHD2 的 N 端附着在细胞膜上，而 C 端则与肌动蛋白结合蛋白结合。 结合后，EHD2与肌动蛋白细胞骨架连接，形 …

2017年2月21日 · The EH-domain–containing protein 2 (EHD2) is a dynamin-related ATPase that confines caveolae to the cell surface by restricting the scission and subsequent endocytosis of these membrane pits. For t...

2022年11月24日 · We propose a model where caveolins, cavins, and EHD2 assemble as a cohesive structural unit regulated by intermittent associations with pacsin2 and EHBP1. These coats can flatten and curve to...

编码的蛋白质通过 N 末端结构域与肌动蛋白细胞骨架相互作用，并通过 C 末端 EH 结构域与 EH 结构域结合蛋白结合。 这种相互作用似乎将网格蛋白依赖性内吞作用与肌动蛋白联系起来，表明该基因产物参与了内吞途径。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the EH domain-containing protein family.

2025年2月8日 · EHD2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Human Colon Cancer. EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. EHD2-controlled caveolar dynamics orchestrates the activity and regulation of eNOS/nitric oxide and Ca2+ channel localization at the plasma membrane.

2024年4月13日 · EH domain-containing protein 2 (EHD2) is a member of the EHD protein family and is mainly located in the plasma membrane, but can also be found in the cytoplasm and endosomes. EHD2 is also a nuclear-cytoplasmic shuttle protein. After entering the cell nuclear, EHD2 acts as a corepressor of transcription to inhibit gene transcription.

2025年1月2日 · 本文将详细介绍EHD2基因的常见突变类型及其可能的生物学后果。我们将探讨点突变、插入缺失、剪接突变等突变类型，并分析这些突变如何影响基因功能，进而可能增加疾病风险。 EHD2基因简介 EHD2基因，也称为EH domain containing 2，位于人类染色体19q13.33。这个基因编码的蛋白质含有EF-hand结构域，这是 ...