HPV-encoded E6 and E7 genes are viral oncogenes that have a crucial role in cell transformation. In uterine cervical cancers, E6 and E7 from high-risk HPV are integrated into the genome, and their expression inactivates and degrades tumor suppressors p53 and pRb, respectively [1].

2019年1月4日 · However, the HPV E7-mediated block in EBV replication correlated with delayed expression of early differentiation markers. Overall, this study reveals an HPV16-mediated block in EBV replication, through E7, that may facilitate EBV latency and long-term persistence in …

Although E7 is known to interact with a number of cellular regulators, E7 binding and facilitated degradation of the Rb family of pocket proteins is a critical interaction for HPV replication. Here, we explored whether the inhibition of EBV replication by HPV16 E7 could be phenocopied by loss of pRb in differentiated epithelia.

2024年9月18日 · Epstein-Barr virus (EBV) co-infections with human papillomavirus (HPV) have been observed in oropharyngeal squamous cell carcinoma. Modeling EBV/HPV co-infection in organotypic epithelial raft cultures revealed that HPV16 E7 inhibited EBV productive replication through the facilitated degradation of …

Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated cancers account for over 200,000 new cases of cancer and cause 150,000 deaths world-wide.

2023年2月28日 · Using organotypic epithelial raft cultures and genetic interference, we can identify factors required for EBV replication in quiescent cells. Here, we phenocopied HPV16 E7 inhibition of EBV replication through knockdown of pRb. Loss of pRb was found to reduce EBV early gene expression and viral replication.

2023年9月12日 · There is a positive correlation between viral load and expression of HPV E7 oncoproteins in early and advanced stages of cervical cancer and elevated expression of HPV E7 correlates with...

2021年11月26日 · In the present study, we investigated the effect of DNA tumor virus oncoproteins on the PERK-mediated UPR, tumor progression, and treatment response. We demonstrated that LMP1 of EBV and E7 of HPV interacted with PERK through a conserved transmembrane motif, which subsequently inhibited PERK oligomerization and activity.

2014年8月21日 · To identify the novel epitopes from the human papillomavirus type 18 E7 which can sensitize PBMCs of four different major HLA class I A allele.

2016年9月24日 · 癌蛋白（E6和E7）的表达与促进E7表达基因的超甲基化模式有关，通常通过DNMT1s维持，并通过miRNA失调维持[70]。 E7抑制MAPK还可以阻碍上皮分化，从而促进突变。