Dyneins are a family of cytoskeletal motor proteins (though they are actually protein complexes) that move along microtubules in cells. They convert the chemical energy stored in ATP to mechanical work.

2023年12月18日 · Dyneins are a family of motor proteins that carry out motility and force generation functions towards the minus end of microtubule filaments.

2013年9月25日 · Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a wealth of biological processes, including ciliary beating, cell division and intracellular transport. The large...

Dynein is a minus-end-directed microtubule motor crucial to diverse cellular processes. The unwieldy size of the molecule and the difficulty of expressing and purifying mutants have hampered mechanistic studies of dynein.

Dynein is the primary motor responsible for motility and force generation toward the minus ends of microtubules (MTs) (124, 150) and drives a myriad of cellular processes in eukaryotes (69, 136, 138).

Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has …

2018年1月1日 · Over recent years, the availability of whole-genome sequences for multiple, diverse eukaryotes has allowed unprecedented analysis of the evolution of dyneins. The power of many analyses lies in the ability to delineate full repertoires of dynein subunits and proteins with associated functions.

2025年1月2日 · Dynein is a minus-end-directed microtubule motor protein, which transports a variety of intracellular cargo by hydrolysing ATP to power its movement along microtubule tracks. Axonemal dyneins are...

2018年4月16日 · Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division. Here, we focus on interphase cargoes of...

Cytoplasmic dynein-1 (dynein) is a microtubule motor required for fundamental processes such as intracellular trafficking, organelle positioning, and the function of the mitotic spindle. Dynein activation requires the assembly of a ~4-MDa complex with its cofactor dynactin and a cargo-specific adaptor protein.