
Dynamin - Wikipedia
Dynamin is a GTPase protein responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs.
缢断蛋白 - 维基百科,自由的百科全书
缢断蛋白(英語: Dynamin ,也译为发动蛋白、动力蛋白)是一种与真核生物 內吞作用有关的 GTP酶 ( 英语 : GTPase ) (GTPase),参与 网格蛋白介导的内吞作用 ( 英语 : Receptor-mediated endocytosis ) (clathrin-mediated endocytosis,CME)等各种膜裂变和融合过程。
发动蛋白及其蛋白超家族的功能
发动蛋白(dynamin)作为一种复杂的多结构域蛋白质,因其在促进内吞囊泡形成和断裂,诱导囊泡从质膜脱离过程中发挥重要功能而广为人知。 其经典功能是在网格蛋白介导型胞吞作用中发挥“膜剪刀”的作用,但是由于其结构和功能的多样性,不同同源异构体间具有组织表达和分布差异性,促使其广泛参与细胞内重要的生理过程,因此具有重要的研究价值。 近期研究揭示了发动蛋白的一些非经典功能,包括参与调控网格蛋白介导型胞吞作用(clathrin-mediated …
Dynamin, a membrane-remodelling GTPase - Nature
2012年1月11日 · Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events.
Dynamin 抑制剂 - 知乎 - 知乎专栏
Dynamin抑制剂的广泛应用允许研究细胞信号通路、细胞周期和细胞分裂,以及其他医疗状况,如癌症、神经系统状况和传染病,如 肉毒杆菌中毒 和艾滋病毒。
Dynamin, a membrane remodelling GTPase - PMC - PubMed …
Dynamins are the founding members of a family of GTPases known as dynamin-like proteins (DLPs), which participate in membrane remodelling (Figure 1 and Table 1) and share basic features of domain organization (Box 1). They also have similar catalytic mechanisms and modes of action that differ from those of the Ras superfamily of regulatory GTPases.
The crystal structure of dynamin - Nature
2011年9月18日 · Here we present the crystal structure of an assembly-deficient mammalian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state.
The dynamin superfamily: universal membrane tubulation and …
2004年2月1日 · Classical dynamins belong to a superfamily that includes dynamin-like proteins, optic atrophy 1 (OPA1), mitofusin and Mx proteins. On the basis of sequence homology, domain structure and...
Dynamin-Ⅰ的功能结构域及其在突触囊泡内吞过程中的作用
在神经系统中,突触是神经元间信息传递的桥梁.突触囊泡通过胞吐和内吞作用完成一次突触囊泡循环.Dynamin-I (又称发动蛋白-1),为三磷酸鸟苷酶...
Dynamins at a glance - PMC
Dynamins are associated with diverse cellular processes, including the release of transport vesicles [as in clathrin-mediated endocytosis (CME)], fusion and fission of mitochondria, division of chloroplasts and peroxisomes, cell division, and resistance to viral infections.