2025年3月28日 · DVL3 (Dishevelled Segment Polarity Protein 3) is a Protein Coding gene. Diseases associated with DVL3 include Robinow Syndrome, Autosomal Dominant 3 and Robinow Syndrome, Autosomal Dominant 1. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Autodegradation of the E3 ubiquitin ligase COP1.

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene. [5][6] This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [6]

Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway. Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/beta-catenin/c-Myc/SOX2 pathway in colorectal cancer.

Disheveled (Dsh) 蛋白（Dvl1、Dvl2 和 Dvl3）抑制糖原合成酶激酶-3β，从而增强 β-连环蛋白的稳定性 。Naked 可通过结合 Dsh 蛋白 并调控平面细胞极性通路的 Dsh 活性，从而抑制典型 Wnt/β-连环蛋白通路 。 配体：wnt1，wnt2，wnt3，wnt3a. 受体：LRP5/6，Frizzled家族蛋白. Dvl ...

2022年5月19日 · We demonstrate that DVL1 and DVL3 are necessary for efficient proliferation in human myoblasts and are important for timely myogenic differentiation. DVL1 and DVL3 also contribute to regulation...

Mechanistically, PNPO oxidizes disheveled 3 M282 (DVL3), leading to abnormal activation of the Wnt/β-catenin pathway. Based on the critical sites of PNPO R95/K117, Eltrombopag is identified as a potential therapeutic candidate for MM. In addition, the …

2025年1月7日 · 本文将详细介绍DVL3基因在细胞中的表达调控机制，包括其基本信息、功能、表达调控方式以及在不同生物过程中的作用。 DVL3，全称 dishevelled segment polarity protein 3，是一个位于人类染色体3q27.1的基因。 它编码一种蛋白质，属于Dishevelled segment polarity proteins家族，这个家族在细胞信号传导和发育过程中起着关键作用。 DVL3基因还有另一个名字， KIAA0208，并且在OMIM数据库中的编号是601368，在Ensembl中是ENSG00000161202， …

2024年4月16日 · Title: Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway. Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/beta-catenin/c-Myc/SOX2 pathway in colorectal cancer.

2025年2月4日 · Dishevelled Segment Polarity Protein 3. Chromosome 3 (3q27.1) This gene is similar to the Drosophila dishevelled gene, dsh, which plays a role in regulating cell proliferation [provided by RefSeq, Jul 2008]. GeneCards: DVL3. MedlinePlus Genetics: DVL3. NCBI Gene: 1857. OMIM: 601368. UniProtKB/Swiss-Prot: Q92997.

The DVL3 gene provides instructions for making a protein that plays a critical role in development before birth. It is one of three DVL genes in humans (DVL1, DVL2, and DVL3). The proteins produced from these genes work together in chemical …