DnaA is a protein that activates initiation of DNA replication in bacteria. [1] Based on the Replicon Model, a positively active initiator molecule contacts with a particular spot on a circular …

在DNA复制起始的过程中， RNA聚合酶 对其的作用可能是因其在起点邻近处合成RNA，可形成RNA突环（R-loop），影响起点的结构，因而有利于DnaA的作用。 新手上路

由DnaA,DnaB,DnaC三种蛋白质参与。 DnaA蛋白负责识别复制起点，然后这些蛋白质携带者ATP，并相互靠近，形成起始复合物，促使复制起点区的DNA发生解链。 DnaB蛋白（解旋酶 …

2014年1月1日 · DnaA and DnaC are specifically required at the stage of initiation of DNA replication from the E. coli replication origin (oriC) to load the replicative DNA helicase (DnaB) …

2016年6月8日 · DnaA monomers recognize the replication origin (oriC) by binding double-stranded DNA sequences (DnaA-boxes); subsequently, DnaA filaments assemble and …

2017年12月21日 · This review summarizes the mechanisms of the initiator protein DnaA in replication initiation and its regulation in Escherichia coli . The chromosomal origin …

2009年9月1日 · DnaA has an extremely high affinity (Kd of 10–100 nM) for ATP and ADP, which requires an assisting role for Asp269 within the sensor 1 motif (Kawakami et al., 2006). The …

2007年5月1日 · Recent structural studies of the bacterial protein DnaA have helped to clarify the molecular mechanisms underlying initiator function, and suggest that key structural features of …

2002年11月1日 · In an E. coli cell there are at least three systems that prevent reinitiation of origins that have already initiated: (i) sequestration of oriC and of the dnaA promoter region …

2018年2月28日 · We will discuss the dnaA gene regulation, the special features of the dnaA gene expression, promoter strength, and translation efficiency, as well as, the DnaA protein, its …