Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity.

Dioscin is a spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage. It has a role as a metabolite, an antifungal agent, an antiviral agent, an antineoplastic agent, an anti-inflammatory agent, a hepatoprotective agent, an apoptosis ...

Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease-associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, …

In recent years, dioscin has reached more and more attention with its potent effects to treat liver, kidney, brain, stomach and intestine damages, and metabolic diseases including diabetes, osteoporosis, obesity, hyperuricemia as well as its anti-cancer activities through adjusting multiple targets and multiple signals.

Dioscin, a naturally occurring compound, helps to reduce the complications of diabetes mellitus by regulating glucose and lipid metabolism, protecting islet β cells, improving insulin resistance, and inhibiting oxidative stress and inflammatory response.

2021年12月16日 · Dioscin is a natural steroidal saponin that can be isolated and purified from medicinal plants belonging to the family Dioscoreaceae, including Dioscorea villosa (native to North America), 1 Dioscorea nipponica Makino, 2 Dioscorea zingiberensis C. H. Wright, 3 and Dioscorea panthaica Prain et Burkill (native to China). 4 The therapeutic nature ...

Abstract: Dioscin is the main ingredient of Dioscorea, a traditional medical herb. Traditional theory of Chinese medicine believes that Dioscorea has effects of clearing lung, digesting food, diuresis, improving blood circulation, relaxing muscles and stopping attack of malaria.

Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease-associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, and efficient treatment alternatives.

2018年11月1日 · Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects.

Dioscin is the most important and well documented saponin. It presents antitumor activity, suppresses cancer cells growth, and is cytotoxic towards leukemia and cervical carcinoma cells. Dioscin is also efficient against gastric cancer, breast cancer, alcoholic liver fibrosis and obesity.