The most popular hypothesis circulating within and beyond the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can injure β-cells and have been isolated in pancreatic tissues from diabetic patients.

For over a century, viruses have left a long trail of evidence implicating them as frequent suspects in the development of type 1 diabetes. Through vigorous interrogation of viral infections in individuals with islet autoimmunity and type 1 diabetes ...

2024年5月15日 · Having diabetes increases your chances of getting sick, staying sick longer, or getting severely sick. That's because diabetes makes it harder to fight off infectious diseases, illnesses caused by germs. Find out how you can boost your immune system to …

Some viruses (e.g., those of the enterovirus genus) induce or accelerate type 1 diabetes (T1D) in animal models. Understanding these infections may lead to the development of vaccines for individuals susceptible to T1D. WHY AN ENVIRONMENTAL FACTOR FOR T1D?

2019年12月19日 · Viruses have long been suspected to be involved in the development of type 1 diabetes, an autoimmune disease, but consistent evidence connecting viruses to the condition has been hard to come by. Computer-generated image …

2023年4月1日 · Coxsackie A virus (CAV), coxsackie B virus (CBV), echovirus (ECV), rubella virus (RuV), cytomegalovirus (CMV), mumps (MuV) and rotavirus (RoV) are known to have tropism to β-cell and are therefore classified as diabetogenic viruses.

2024年7月1日 · Among the reported viral infections causing DM in humans, the most studied include coxsackie B virus, cytomegalovirus and hepatitis C virus. The recent COVID-19 pandemic has highlighted the diabetogenic potential of SARS-CoV-2, rekindling interest in the field of virus-induced diabetes (VID).

In this chapter we review the data obtained both in man and in experimental animal models in support of the potential participation of viral infections to Type 1 diabetes pathogenesis, with a particular emphasis on virus-triggered islet inflammation, beta-cell dysfunction and autoimmunity.

2021年6月13日 · Though there is no ‘Diabetes Virus’, multiple agents such as mumps virus, rubella virus, influenza virus, type A hepatitis virus, enterovirus, rotavirus, cytomegalovirus, varicella-zoster virus, human herpesvirus 6, Epstein-Barr virus, and also SARS-CoV-2 have been reported to be associated to diabetes [1, 2].

In this review, we will discuss recent literature that sheds more light on how T2D impairs immune responses to viral infection and how virus-induced activation of the immune system increases risk of development of T2D.