Biologics have been used for various dermatological conditions with some good and some equivocal results. Their use in psoriasis spearheaded trials for use in other dermatoses. However, level of evidence for majority of these unapproved conditions is low. The term ‘biologic’ refers to agents synthesized from the products of living organism. [1] .

Why do dermatologists prescribe a biologic to treat psoriasis? A biologic is an important treatment option for people with moderate-to-severe psoriasis, psoriatic arthritis, or both. For many people, taking a biologic was life changing because it helped control their symptoms when other treatments failed.

Biological treatments are used to treat severe and refractory cases of autoimmune diseases. Biological treatments are very effective, but because of their expense, they are typically reserved for patients who have failed at least three other treatments. What are the contraindications with biological treatments?

Biological agents or treatments, also known as biologics, biologic therapies, or biological response modifiers, are drugs derived from living material (human, plant, animal, or microorganism). They interfere with specific parts of the body's immune system to treat and prevent immune-mediated inflammatory disorders and cancers.

Biologics represent the future of therapeutics, not only in dermatology but also in other fields of medicine. Among all the dermatological disorders it is psoriasis where the biologics have been most evaluated. Vastly different opinions have been expressed about the comparative efficacy of the various biological therapies available for psoriasis.

Biologics are protein molecules produced by recombinant DNA technology, which target the specific sites in the immune-pathogenesis pathway of the diseases. Because of the specific action on immune system, biologics are presumed to have lesser side effect profile compared to the traditional immune-suppressants.

Apr 17, 2013 · Biological therapies provide a targeted approach to treatment through interaction with specific components of the underlying immune and inflammatory disease processes. This review article examines the increasing evidence base for biologics in dermatology, including well-established treatments and novel agents.

Nov 25, 2018 · Biologic therapies are molecules that target specific proteins implicated in immune-mediated disease. This review article highlights the increasing evidence base for biologics in dermatology for off-label use.

Several biologic agents have been approved for use in dermatology and other disciplines of medicine. However, based on the mechanism of action and a track record of the response, these agents are being increasingly used for off-label purposes to garner control of more remote and difficult disease pr …

Apr 17, 2013 · Biological therapies provide a targeted approach to treatment through interaction with specific components of the underlying immune and inflammatory disease processes. This review article examines the increasing evidence base for biologics in dermatology, including well-established treatments and novel agents.