We confirmed a very efficient deletion of DDB1 in DDB1F/F; Mx1-Cre+/− mouse liver after one i.p. injection of polyinosinic:polycytidylic acid [poly (I:C)], which induces an IFN response to …

Mechanistically, DDB1 deficiency attenuated hepatic steatosis by downregulating the expression of lipid synthesis and uptake genes. We identified high-mobility group box 1 as a key …

2020年6月1日 · After 3-week high-fructose diet feeding, both Ddb1 liver-specific knockout and AAV-TBG-Cre-injected Ddb1flox/flox mice showed significantly reduced ChREBPα, lipogenic …

Here we show that CUL4-DDB1-CDT2 E3 ligase ubiquitinates CRY1 and promotes its degradation both in vitro and in vivo. Depletion of the major components of this E3 ligase …

DDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in diverse cellular functions, including nuclear ex-cision repair, regulation of the cell cycle, and …

2020年9月15日 · Chondrocyte-specific DDB1 knockout mice exhibit dwarfism and dyschondroplasia. The mutant growth plates in tibia and femur are structurally disordered with …

2007年2月2日 · Here we report that tissue-specific deletion of the UV-damaged DNA-binding protein 1 (DDB1) in mouse epidermis led to dramatic accumulation of c-Jun and p21Cip1, …

2010年12月12日 · By using mice with inducible or constitutive deletion of DDB1 in hepatocytes, we show that DDB1 loss prevents hepatocytes to replicate DNA, induces compensatory …

Mechanistically, DDB1 stabilizes ChREBPα through CRY1, a known ubiquitination target of DDB1 E3 ligase. Finally, overexpression of a degradation-resistant CRY1 mutant (CRY1-585KA) …

该研究揭示了DDB1能够以不依赖于CUL4的方式促进脂肪细胞分化过程中转录事件起始的分子机制，并发现了Pol II pausing release在调控脂肪细胞分化中的生理作用。