2023年11月22日 · Damage-specific DNA binding protein 1 (DDB1) is a component of the Cullin4A/B-RING E3 ubiquitin ligase (CRL4) complex and functions as an adaptor protein...

2005年9月28日 · The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to …

We provide the molecular basis for DDB2 receptor-mediated cyclobutane pyrimidine dimer recognition in chromatin. The structures of the fully assembled DDB1-DDB2-CUL4A/B-RBX1 …

2011年12月1日 · Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced …

2006年1月13日 · With the crystals of isolated DDB1 BPB domain and the available polyalanine model, the structure of DDB1-BPB was determined by molecular replacement (MR) in …

2014年7月16日 · IMiDs target the E3 ubiquitin ligase CUL4–RBX1–DDB1–CRBN (known as CRL4 CRBN) and promote the ubiquitination of the IKAROS family transcription factors IKZF1 …

The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small (DDB2) subunit. DDB1 contains 1140 amino acids, …

2006年10月5日 · Distinct from all known cullin adaptors, DDB1 is a large multidomain protein featuring an independent β-propeller (BP) domain (BPB) flexibly connected to a clam-shaped …

Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the …

Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two …