2025年3月30日 · DDB1 (Damage Specific DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with DDB1 include White-Kernohan Syndrome and Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network.

Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the nucleotide excision repair pathway. DDB1 and DDB2 form a complex that promotes the global genome repair (GG-NER) …

Results suggest that DDB1 prevents DNA lesions from accumulating in replicating human cells, in part by regulating Cdt1 degradation. the interaction with DDB1 mediates Vpr-induced apoptosis and UNG2/SMUG1 degradation and impairs the repair of UV-damaged DNA, which could account for G(2) arrest and apoptosis

2023年11月22日 · Damage-specific DNA binding protein 1 (DDB1) is a component of the Cullin4A/B-RING E3 ubiquitin ligase (CRL4) complex and functions as an adaptor protein between Cullin4A/B (CUL4A/B)...

2025年1月5日 · Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication. Tang KF, Xie J, Chen M, Liu Q, Zhou XY, Zeng W, Huang AL, Zuo GQ, Wang Y, Xiang R, Ren HTang KF, et al .

DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity).

2025年2月9日 · HIV-1 Rev interacting protein, DNA damage-binding protein 1 (DDB1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with DDB1 is increased by RRE

The DDB1 gene encodes damage-specific DNA-binding protein 1, which plays a vital role in the DNA damage response, specifically in the nucleotide excision repair pathway where it functions as part of the CUL4-DDB1 ubiquitin E3 ligase complex (CRL4).

The DNA damage-binding protein 1 (DDB1) is part of the CUL4–DDB1 ubiquitin E3 ligase complex (CRL4), which is essential for DNA repair, chromatin remodeling, DNA replication, and signal transduction.

2011年12月1日 · Damage-specific DNA binding protein 1 (DDB1) is a conserved protein that is involved in the nucleotide excision repair pathway (NER) as a component of the damaged DNA binding protein complex (UV–DDB) that binds to UV-damaged DNA (Chu and Yang, 2008).