乙酸 豆塞外 佛波酯 （12-o-tertradecanoylphordol-13-acetate, TPA;或phorbol-12-myristate-13-acetate,PMA）是一种促 肿瘤 剂，由于基结构与DAG相似，可在很低浓度下模拟DAG，活化PKC，使PKC亲和力增至10-7M。PKC是TPA的受体，当TPA插入细胞膜后可以替代DAG而直接活 …

DAG regulates the intracellular localization of PKD and also activates PKD through PKC by phosphorylation. The PKC-PKD signaling cascade is crucial to PKD function in cells. Important discoveries have been made regarding the roles of PKD in cell growth, gene expression, survival, motility, protein trafficking and lymphocyte biology.

In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.

2021年1月31日 · dag是机体内主要的pkc激动剂。生理情况下，dag主要来源于磷酸肌醇的代谢和磷脂酰胆碱的裂解，但也可由脂质 前体 在磷脂酶a2的作用下释放出游离脂肪酸而生成。高血糖激活pkc信号通路主要通过dag途径。

响应细胞外刺激，如激素、生长因子和神经递质刺激后，plc 水解磷脂酰肌醇-4,5 二磷酸 (pip2) 并产生第二信使肌糖 1,4,5 三磷酸 (ip3) 和甘油二酯 (dag)。 至少已发现四种 PLCs 的家族成员：PLCβ、PLCγ、PLCδ 和 PLCε。

2020年5月28日 · Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated ...

结合gprc的主要是camp, ip3 和 dag，pka, pkc, plc和pi3k等也涉及了gprc的下游调控。 在这里我列举几个较为重要的：腺苷酸环化酶-camp-pka、磷脂酶c（ip3-ca2+、dag-pkc）、离子通道和mapk、pi3k信号通路。 （1）腺苷酸环化酶-camp-pka

2004年1月8日 · 高血糖可引起多种组织细胞内二脂酰甘油(dag)水平升高，dag可激活蛋白激酶c(pkc)。 最近研究表明，持续高血糖引起的DAG-PKC系统激活与糖尿病多种血管异常关系密切。

蛋白激酶 c (pkc) 家族成员调控大量的细胞反应，包括基因表达、蛋白分泌、细胞增殖和炎性反应。其基本的蛋白结构包括一个 n 端调节区，该调节区由一个铰链区连接至 c 端激酶区域。

Protein kinase D (PKD), a novel DAG receptor, has been the subject of intense investigation in recent years. DAG regulates the intracellular localization of PKD and also activates PKD through PKC by phosphorylation. The PKC–PKD signaling cascade is crucial to PKD function in cells.