Desmocollin-2 is a protein that in humans is encoded by the DSC2 gene. [5] [6] Desmocollin-2 is a cadherin-type protein that functions to link adjacent cells together in specialized regions known as desmosomes. Desmocollin-2 is widely expressed, and is the only desmocollin isoform expressed in cardiac muscle, where it localizes to intercalated ...

2024年12月24日 · DSC2 (Desmocollin 2) is a Protein Coding gene. Diseases associated with DSC2 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 11 and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are …

桥粒糖连同桥粒芯糖蛋白是钙粘蛋白样跨膜糖蛋白，是桥粒的主要成分。 桥粒是有助于抵抗剪切力的细胞-细胞连接，在受到机械应力的细胞中含量很高。 该基因与 18 号染色体上的其他 desmocollin 家族成员一起被发现。 该基因的突变与致心律失常性右心室发育不良 11 有关，并且已经在几种类型的癌症中描述了蛋白质表达减少。 可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 2 月] This gene encodes a member of the desmocollin protein subfamily.

The DSC2 gene provides instructions for making a protein called desmocollin-2. This protein is found in many tissues, although it appears to be particularly important in the heart muscle and skin. Desmocollin-2 is a major component of specialized structures called desmosomes.

DSC2 is a useful immunohistochemical marker for separation of Urothelial carcinoma with squamous differentiation from pure Urothelial carcinoma; The Dsc2 exhibit microtubule-dependent transport in epithelial cells but use distinct motors to traffic to the plasma membrane.

2024年9月18日 · Title: A homozygous DSC2 deletion associated with arrhythmogenic cardiomyopathy is caused by uniparental isodisomy. Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration.

DSC2是位于18号染色体的 基因。 该基因编码去胶原蛋白亚家族的一个成员。 德莫科林斯和地丝粒蛋白是钙粘素样跨膜糖蛋白，是桥粒的主要组成部分.苔藓体是一种细胞-细胞连接，有助于抵抗剪切力，并发现高浓度的细胞受到机械压力。 该基因与18号染色体上的其他去胶原蛋白家族成员在一起发现。 该基因突变与致 心律失常 性右心室发育不良-11有关，并已在多种类型的癌症中表达降低。 选择性剪接导致多个转录体变异。 [由RefSeq提供，2015年2月] [1] DSC2是位于18号染 …

2024年9月18日 · DSC2 Suppresses the Metastasis of Gastric Cancer through Inhibiting the BRD4/Snail Signaling Pathway and the Transcriptional Activity of β-Catenin. Sun C, Wang L, Du DD, Ji JB, Yang XX, Yu BF, Shang PF, Guo XLSun C, et al .

2023年3月16日 · In the present study, we describe the pro-metastatic role of the desmosomal protein desmocollin 2 (DSC2) in breast cancer. Methods: We analysed the prognostic role of DSC2 at mRNA and protein level using microarray data, western blot analysis and immunohistochemistry.

2016年6月8日 · Recombinant-expressed mutant DSC2 in HEK293 and HeLa cells confirmed a stable, partially processed truncated protein with cytoplasmic and membrane localization. Mild palmoplantar hyperkeratosis was observed in only 1 of …