Cell-type specific changes in PKC-delta neurons of the central
2022年7月20日 · Louvain clustering identified 13 distinct subclusters of CeA GABAergic neurons enriched with gene markers for dopamine receptors D1 and D2 (Drd1, Drd2), PKCδ (Prkcd), …
Protein Kinase C Beta Regulates the D2-Like Dopamine Autoreceptor
The focus of this study was the regulation of the D2-like dopamine autoreceptor (D2 autoreceptor) by protein kinase Cβ, a member of the protein kinase C (PKC) family. Together with the …
In Situ Regulated Dopamine Transporter Trafficking: There’s No …
DRD2-mediated and Gi-coupled DAT plasma membrane delivery. The D2 DA receptor subtype (DRD2) is a G i-coupled receptor expressed widely throughout the striatum. Presynaptically, …
Dopamine D2 receptor regulates cortical synaptic pruning in …
2021年11月8日 · Dopamine D2 receptor (Drd2) is associated with several neuropsychiatric diseases and is the target of some antipsychotic drugs. Here we generate self-reporting Drd2 …
Nature | 多巴胺受体D2介导的信号传递分子机制 - 知乎
多巴胺受体家族属于 G蛋白 （由Gα和Gβγ三个亚基组成）偶联受体超家族（G-Protein-Coupled Receptor， GPCR），包含五个成员：DRD1、 DRD2 、DRD3、DRD4和DRD5。 其 …
DRD2-Mediated AMPK Ubiquitination Regulates the Occurrence …
Results: The study found that activation of PKC leads to the elevation and internalisation of DRD2 in a high-fat environment. Knockdown of DRD2 in mouse liver can effectively interfere with the …
研究揭示星形胶质细胞多巴胺受体D2在神经系统自身免疫性疾病中 …
2022年7月27日 · 7月26日，Journal of Experimental Medicine在线发表了题为 《抑制星形胶质细胞多巴胺受体D2缓解多发性硬化症动物模型中枢神经炎症》 的研究论文。 该研究由中国科学 …
Presynaptic Gq-coupled receptors drive biphasic dopamine …
2023年2月1日 · Taken together, these results clearly demonstrate that presynaptic Gq-coupled receptor activation drives biphasic DAT trafficking that is facilitated by Gq-stimulated DA …
Apo-ghrelin receptor forms heteromers with DRD2 in …
We identified subsets of neurons in the brain that co-express the dopamine receptor subtype-2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy and Tr …
Protein kinase C beta regulates the D₂-like dopamine
PKC regulates neuronal signaling via several mechanisms, including desensitizing autoreceptors to increase the release of several different neurotransmitters. Here, using both PKCβ(-/-) mice …