2022年8月7日 · Based on his 1997 study, Webb’s Depth of Knowledge is a framework that categorizes contexts — prompts, scenarios and challenges — into four levels of rigor. As students progress through the DoK levels, they will face contexts in assessments that demand learning and thinking at deeper cognitive stages.

2024年12月24日 · DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity).

2024年1月22日 · DOK理论 和方法主要指向教学任务、活动和任务的设计，是推动学生深度学习和积极参与的学习工具，成为培养学生 高阶思维 的教学设计工具。 DOK通过不同的活动、任务和问题检测学生的认知水平，强调的不是内容的难度、而是学习的复杂度。 DOK将学生的认识水平分成四个等级，研究者根据其不同等级的思维要求设计和开发相应的活动、任务和问题，使得教育实践者能够设计有质量、促进学生深度学习的教学任务、活动和问题。 DOK层级. 第一层：回忆和 …

2023年3月27日 · Norman Webb explains how his Depth of Knowledge (DOK) framework helps teachers evaluate the cognitive complexity of a task or lesson.

Design a mathematical model to inform and solve a practical or abstract situation. Requires an investigation, time to think and process multiple conditions of the problem. Most on-demand assessments will not include Level 4 activities. Making value judgments about the method.”

2018年11月2日 · An Item at DOK level 3 or 4 requires complex reasoning, strategic and extended thinking about the concepts of the content and a real-world context, and especially at a level 4 that requires research, investigation, and application often over an extended period of time.

2009年6月15日 · Loss-of-function experiments using RNA interference constructs show that Dok-4 is a negative regulator of ERK phosphorylation, IL-2 promoter activity, and T cell proliferation. Exogenous expression of wild-type Dok-4 induces a significant activation of Rap1, which is involved in the regulation of ERK.

2005年7月15日 · We found that Dok-4 inhibited activation of the Erk substrate Elk-1 by Ret and by the Src kinase Fyn in epithelial cells. On the other hand, by using different approaches and cellular systems, Grimm et al. (6) and Cai et al. (7) have suggested a …

2009年6月15日 · Loss-of-function experiments using RNA interference constructs show that Dok-4 is a negative regulator of ERK phosphorylation, IL-2 promoter activity, and T cell proliferation. Exogenous expression of wild-type Dok-4 induces a significant activation of Rap1, which is involved in the regulation of ERK.

2005年7月15日 · Dok-4-WT enhanced tumor necrosis factor-alpha (TNF-alpha)-mediated reactive oxygen species (ROS) production, supporting the functional relevance of a Dok-4-Src-complex I/ROS signaling pathway in mitochondria. Finally, Dok-4 enhanced TNF-alpha-mediated NF-kappaB activation, whereas this was inhibited by transfection with Dok-4 small interfering RNA.