2025年3月28日 · DNMT1 (DNA Methyltransferase 1) is a Protein Coding gene. Diseases associated with DNMT1 include Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant and Neuropathy, Hereditary Sensory, Type Ie. Among its related pathways are RNA Polymerase I Promoter Opening and Signaling by ALK in cancer.

2023年2月7日 · 而DNMT1表达水平增加受肿瘤相关巨噬细胞（TAM）调控，DNMT1上调通过肿瘤抑制因子凝溶胶蛋白（Gelsolin）加重GC，而后者介导表观遗传抑制。 先前研究表明，由MHC（major histocompatibility complex）介导的抗原呈递是抗肿瘤免疫和对PD-1/PD-L1靶向治疗反应的重要修饰因子 ...

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. [5] Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.

为了解决甲基化丢失的问题，DNMT1就派上了用场——DNMT1负责准确复制DNA甲基化形式，在DNA复制的过程中起着维持甲基化的作用（如下图所示）；而DNMT3a/3b的作用则是在原本任意一条DNA单链都不存在甲基化修饰的位点加上甲基化修饰，即从头（de novo）甲基化。

2022年11月21日 · Nature Communications - DNMT1 is an essential for maintaining genomic DNA methylation. Here, we report the cryo-EM structure of DNMT1 bound to ubiquitinated H3 and hemimethylated DNA,...

关于 Dnmt1 Chromosome 9: 20,818,505-20,871,184 reverse strand.GRCm39:CM001002.3 This gene has 7 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 21 phenotypes.

DNMT1 regulates miR-20a/TXNIP-mediated pyroptosis of retinal pigment epithelial cells through DNA methylation. DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells.

2012年2月16日 · DNMT1-related disorder is a degenerative disorder of the central and peripheral nervous systems comprising a phenotypic spectrum that includes hereditary sensory and autonomic neuropathy type 1E (HSAN1E) and autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN).

DNMT1-RFD: Cytosine specific DNA methyltransferase replication foci domain (400 - 533)

Nature|朱冰组首次在体内证实DNMT1可作为起始性DNA甲基转移酶，揭示卵子发生过程中DNA甲基化模式建立的机制—专家点评 BioArt生物艺术 科研等 2 个话题下的优秀答主