CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') [5] or DNAM-1 (DNAX Accessory Molecule-1) [5] is a ~65 kDa immunoglobulin-like transmembrane glycoprotein expressed on the surface of natural killer cells, NK T cell, B cells, dendritic cells, hematopoietic precursor cells, platelets ...

dnam-1 是该家族中唯一的激活型受体分子。 因此，对 DNAM-1 与其配体的作用机制的研究，不仅能够阐明其激活 NK 细胞的作用机制，而且对以 DNAM-1 为靶点的免疫治疗性药物的开发具有重要价值。

The most famous member of this family, DNAX accessory molecule (DNAM-1, CD226), is an adhesion molecule that control NK cell cytotoxicity and interferon-γ production against a wide range of cancer and infected cells.

2023年6月7日 · DNAM-1 is a major NK cell activating receptor and, together with NKG2D and NCRs, by binding specific ligands, strongly contributes to mediating the killing of tumor or virus-infected cells.

2019年1月3日 · 最近，PNAS (《美国科学院院报》)报道了中科院微生物所高福院士团队关于DNAM-1与配体CD155互作机制的重要研究成果。 研究团队解析了人DNAM-1和小鼠DNAM-1分子的胞外段高分辨率三维结构。 通常而言，具有多个Ig样结构域的蛋白，其Ig样结构域间通常形成一种“头尾相接”的串联方式（见CD155分子）。 这种“念珠”样的排列导致相邻两个Ig结构域之间具有一定的柔性，便于其通过构象调整而结合受体/配体分子。 研究人员发现，由两个V型免疫球 …

DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa includ- ing two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell–mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloanti- gen-specific T cells.

2017年5月31日 · DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has...

2015年10月6日 · DNAM-1 (CD226) is a cell surface glycoprotein that functions as an adhesion molecule to synergize with activating receptors and trigger NK cellmediated cytotoxicity upon interaction with its ligands CD155 and CD112 [2].

2015年11月16日 · DNAM-1 (CD226) is an activating receptor expressed on natural killer (NK) cells, CD8 (+) T cells, and other immune cells. Upon recognition of its ligands, CD155 and CD112, DNAM-1 promotes NK cell-mediated elimination of transformed and virus-infected cells. It also has a key role in expansion and maintenance of virus-specific memory NK cells.

2023年6月8日 · DNAM-1 is a major NK cell activating receptor and, together with NKG2D and NCRs, by binding specific ligands, strongly contributes to mediating the killing of tumor or virus-infected cells. DNAM-1 specifically recognizes PVR and Nectin-2 ligands that are expressed on some virus-infected cells and on …