DNA-PKcs - Wikipedia
DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs …
Prkdc基因及其在NHEJ中的作用 - 知乎
DNA-PKcs是NHEJ途径的关键组成部分，也是一种潜在的癌症治疗靶标。 我们可以通过抑制DNA-PKcs活性，使肿瘤细胞对电离辐射（IR）和DSB诱导剂敏感，从而提高放疗和化疗效果。
DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
2020年12月23日 · DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than …
DNA-PKcs：DNA损伤反应的多方面参与者,Frontiers in Genetics
DNA依赖性蛋白激酶催化亚基（DNA-PKcs）是磷脂酰肌醇3激酶相关激酶家族的成员，可磷酸化700多种底物。 DNA-PKcs作为核心酶，与Ku80 / Ku70异二聚体形成活性DNA-PK全酶，在细 …
DNA依赖性蛋白激酶的自磷酸化和自激活,Genes - X-MOL
DNA 依赖性蛋白激酶催化亚基 (DNA-PKcs) 是磷脂酰肌醇 3-激酶相关激酶家族的成员，在存在 Ku 复合物和双链 DNA 的情况下磷酸化底物蛋白的丝氨酸和苏氨酸残基。
Nature | 何源等揭示DNA非同源末端连接修复的结构分子机制 - 知乎
非同源末端连接修复 （non-homologous end-joining, NHEJ）是细胞内主要的DNA双链断裂修复方式之一。 与同源重组不同，由于不需要同源DNA作为修复模版，NHEJ在细胞周期的各个阶段 …
Secrets of DNA-PKcs beyond DNA repair - PMC
The canonical role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in repairing DNA double-strand breaks combined with its reported dysregulation in several malignancies …
Human DNA-dependent protein kinase activation mechanism
2023年1月5日 · DNA-dependent protein kinase (DNA-PK), a multicomponent complex including the DNA-PK catalytic subunit and Ku70/80 heterodimer together with DNA, is central to...
DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
2020年12月22日 · DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than …
DNA-PKcs, a player winding and dancing with RNA metabolism …
2025年3月4日 · This review summarizes several aspects of DNA-PKcs regulation of RNA metabolism, including its impact on transcriptional machinery, alternative splicing, and …