错配修复 (Mismatch Repair，MMR) 是指在含有错配碱基的 DNA 分子中，使核苷酸序列恢复正常的修复方式。 当 MMR 基因发生胚系突变或甲基化时将导致 MMR 功能下降，致使 DNA序列中的碱基错配、缺失或插入不能被修复。

DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage. [1][2]

2007年12月24日 · DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for...

2017年7月1日 · DNA mismatch repair (MMR) is a highly-conserved DNA repair pathway that plays major roles during DNA replication, repair and recombination, as well as additional roles during meiosis in eukaryotes and immunoglobulin maturation/diversification in mammals.

DNA mismatch repair (MMR) proteins are essential for the recognition and correction of sporadic genetic mutations that occur during DNA replication. Deficient MMR function (dMMR) leads to an increased risk of development of neoplasia.

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to ...

DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired bases that arise through replication errors, during homologous recombination, and as a result of DNA damage.

2006年4月12日 · By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator...

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination.

5 天之前 · MMR is a key process regulating the length of microsatellites, and deficient MMR (dMMR) hampers the repair of microsatellite indels that can lead to frameshift mutations, typically in non-coding DNA.