Meiotic recombination protein Dmc1 is a homolog of the bacterial strand exchange protein RecA. Dmc1 plays the central role in homologous recombination in meiosis by assembling at the sites of programmed DNA double strand breaks and carrying out a search for allelic DNA sequences located on homologous chromatids.

2025年3月30日 · DMC1 (DNA Meiotic Recombinase 1) is a Protein Coding gene. Diseases associated with DMC1 include Azoospermia and Primary Ovarian Insufficiency. Among its related pathways are Meiosis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include nucleotide binding and ATP-dependent activity, acting on DNA.

2025年2月8日 · This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis.

2025年2月8日 · This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis.

In yeast an Escherichia coli RecA-like gene, DMC1, is expressed in meiotic prophase and its product co-localizes with Rad51 protein on zygotene chromosomes. We have cloned the mouse and human homologs of the yeast DMC1 gene.

2012年10月31日 · DMC1 contains the 2 nucleotide-binding motifs and the single- and double-stranded DNA-binding sites that are conserved in the RecA-like protein family. The authors identified an alternatively spliced transcript, called DMC1-D, that encodes a 285-amino acid protein with a deletion between the nucleotide-binding motifs.

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis.

The DMC1 gene is found in most eukaryotes, including Saccharomyces cerevisiae, plants, mice, and humans. Interestingly, all Dipteran insects, including Drosophila, are missing DMC1, and it appears to have been lost independently in other clades, including fission yeast and some nematodes [73].

2002年6月27日 · DMC1 ("Disruption of Meiotic Control") was identified in a screen for meiotically induced genes in yeast (1). DMC1 is required for meiotic recombination (reviewed in 8). In its absence, cells fail to repair the double strand breaks that are formed throughout the genome and then arrest at pachytene during the first meiotic division (1).

Description: Homo sapiens DNA meiotic recombinase 1 (DMC1), transcript variant 1, mRNA. (from RefSeq NM_007068) RefSeq Summary (NM_007068): This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis.