2025年3月30日 · DLG4 (Discs Large MAGUK Scaffold Protein 4) is a Protein Coding gene. Diseases associated with DLG4 include Intellectual Developmental Disorder, Autosomal …

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two …

2023年6月22日 · DLG4-related synaptopathy is characterized by developmental delay, intellectual disability (most commonly in the mild-to-moderate range), and autism spectrum disorder. …

2021年2月17日 · Postsynaptic density protein-95 (PSD-95), encoded by DLG4, regulates excitatory synaptic function in the brain. Here we present the clinical and genetic features of 53...

该基因编码膜相关鸟苷酸激酶 (MAGUK) 家族的成员。 它与另一种 MAGUK 蛋白 DLG2 异源多聚化，并被募集到 NMDA 受体和钾通道簇中。 这两种 MAGUK 蛋白可能在突触后位点相互作 …

The DLG4 protein enhances the resensitization of the D1 DA receptor by accelerating D1 receptor recycling to the cell membrane. This study found that the PSD-95 protein level significationalty …

The DLG4 gene provides instructions for making a protein that plays a role in nerve cells (neurons) in the brain. The DLG4 protein is found at synapses, which are the connections …

2025年2月8日 · findings demonstrate that DLG4 gene disruption in mice produces a complex range of behavioral and molecular abnormalities relevant to autism spectrum disorders and …

DLG4 belongs to the discs large (DLG) subfamily of the membrane-associated guanylate kinase (MAGUK) family (see DLG1; 601014). DLG4 interacts with both N-methyl-D-aspartate (NMDA) …

2017年12月1日 · The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are …