DJ-1 is a DNA damage response protein that is recruited to sites of DNA damage where it participates in the repair of DNA double-strand breaks through the processes of non …

2022年9月1日 · 研究组选择了蛋白质/核酸脱糖苷 (DJ-1)蛋白 (一种重要的氧化应激调节蛋白)中的一个位点进行进一步的功能验证。 结果表明， DJ-1中的C106在铁死亡过程中被氧化，从而阻 …

In this review, we discuss the role of DJ-1 in the physiopathology of several immune and inflammatory diseases including sepsis, allergic diseases, atherosclerosis (AS), and multiple …

2022年5月1日 · DJ-1 acts on signaling cascades and transcription factors-related pathways. DJ-1 induces cell survival and proliferation by activating ERK1/2, PI3K/Akt and Nrf2. DJ-1 mitigates …

DJ-1 is a small, highly conserved protein of 189 amino acids, which is ubiquitously expressed and dimeric under physiological conditions. In humans, DJ-1 is encoded by the PARK7 gene, …

2023年1月1日 · With our study, we shed light on different aspects of DJ-1 physiology in vivo, through a fine characterization of the DJ-1 null fly model. Loss of DJ-1 leads to hypoactivity …

摘要: 线粒体功能障碍在帕金森病 (Parkinson's disease, PD)发生过程中非常重要,DJ-1蛋白可以参与线粒体的功能调节,从而维持线粒体的正常功能。 DJ-1基因突变及功能丧失时,则会导致线粒 …

DJ-1是PARK7基因编码的属于 肽酶 C56的蛋白质家族的一个成员。 它可以作为一个积极的 雄激素受体 介导的转录调节子。 它也可以用作氧化还原敏感的分子伴侣，氧化应激传感器。 DJ-1蛋 …

Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson's disease, increasing …

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological …