2025年3月30日 · Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes.

ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene. [5][6] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.

DDX1 binds HIV-1 rev response element to promote virus assembly. DDX1, a RNA helicase also implicated in DSB repair, interacts with RIF1. Recruitment of DDX1 to DSBs is dependent on RIF1. DDX1 is also required for chromatin loading of BLM to ionizing radiation-induced DSBs.

2018年12月14日 · Since regulation at the translational level is generally mediated through RNA-binding proteins, using RNA antisense purification coupled with mass spectrometry, we identify a novel insulin mRNA-binding protein, namely, DDX1, that is sensitive to palmitate treatment.

In this study, we identified a novel insulin mRNA-binding protein, namely, DDX1, that is responsible for the palmitate (PA)-induced inhibition of insulin translation. DDX1 belongs to the DEAD box helicase superfamily, which consists of 37 members in humans (18).

The DEAD-box RNA helicase (DDX) family plays a critical role in the growth and development of multiple organisms. DDX1 is involved in mRNA/rRNA processing and mature, virus replication and transcription, hormone metabolism, tumorigenesis, and tumor ...

DDX1 is a nuclear protein that is widely expressed in the early stages of development, but displays a restricted expression pattern in later stages [76]. DDX1 interacts with factors involved in RNA metabolism [77,78].

2022年7月1日 · Ddx1 knockout causes stalling of embryos at the 2-4 cell stages. Here, we identify a DDX1-containing membrane-bound calcium-containing organelle with a nucleic acid core.

DDX1 is a member of the DEAD box protein family that is overexpressed in a subset of retinoblastoma and neuroblastoma cell lines and tumors. DDX1 is found primarily in the nucleus, where it forms two to four large aggregates called DDX1 bodies.

DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene. DDX1, a member of the DEAD box RNA helicase family, plays a critical role in testicular tumors. However, it remains to be clarified whether DDX1 is involved in other types of malignant tumors such as colorectal cancer.