Epidemiologic studies revealed either positive or negative associations between exposure to DDT and tumor development, but there has been no clear evidence that DDT causes cancer in humans. In experimental animals, tumor induction by …

Associations between exposure to DDT and several types of cancer have been extensively investigated in epidemiological studies. The pertinent studies reviewed by the Working Group are summarized here according to study design and cancer site. Several meta-analyses were also available to the Working Group.

2019年2月19日 · All women exposed to high levels of DDT are at increased risk for breast cancer through age 54, but the timing of cancer risk depends on when they were first exposed, according to a new study published in the Journal of the National Cancer Institute.

2021年7月1日 · Laboratory studies, including one by Cohn in 2019, have shown that DDT and other EDCs can lead to effects across generations via epigenetic changes, which alter how genes turn on and off. Cohn is...

Some studies suggested that DDT exposure may be associated with certain cancers (lung cancer and lymphomas); however, the lack of control for exposure to other chemicals, small study size, insufficient data on confounding factors (e.g., incomplete information on tobacco use), and short follow-up time for long-latency cancers limited the ability ...

2015年6月22日 · There is strong evidence that lindane causes immunosuppressive effects that can operate in humans. The insecticide DDT was classified as “probably carcinogenic to humans” (Group 2A). DDT was used for the control of insect-borne diseases during World War 2; subsequently it was widely applied to eradicate malaria and also used in agriculture.

This volume of the IARC Monographs provides evaluations of the carcinogenicity of DDT and lindane (both organochlorine insecticides), and 2,4-D (a chlorophenoxy herbicide). DDT is one of the most studied chemicals of environmental concern. It came into widespread use for disease-vector control and a …

Epidemiological studies found positive associations between exposure to DDT aNHL, nd testicular cancer, and liver cancer. There was also strong experimental evidence that DDT can suppress the immune system and disrupt sex hormones. However, overall there was no association between breast cancer and DDT levels measured in samples of blood or fat.

2025年3月20日 · In the three decades DDT was used in the US, it dramatically lowered rates of malaria, increased crop yields, and likely contributed to thousands of cancer diagnoses. DDT (dichloro-diphenyl-trichloroethane) was one of the first synthetic insecticides used at industrial and commercial scale.

This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer. We reviewed the published literature on exposure to DDE and breast cancer risk to update a ...