DDR1 activation in macrophage promotes IPF by regulating …
In this study, we firstly reported DDR1 activation in macrophages to play a role in IPF via inflammasome activation and macrophage responses. In addition, DDR1 inhibitors DDR1-IN-1 …
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the
2021年11月24日 · In this study we designed and synthesized a new indazole derivative XBLJ-13, and identified XBLJ-13 as a highly specific and potent DDRs inhibitor with anti-inflammation …
Identification of novel inhibitors of DDR1 against idiopathic …
2016年4月26日 · The results suggested the discoidin domain receptor 1 (DDR1) and downstream c-Jun N-terminal kinases (JNK) pathway may play important roles in the progression of IPF. …
Research progress of DDR1 inhibitors in the treatment of multiple …
2024年3月15日 · In the bleomycin (BLM)-induced rat model of idiopathic pulmonary fibrosis (IPF), compound 9 inhibited excessive collagen deposition and reduced airway inflammation. …
DDR1 role in fibrosis and its pharmacological targeting
2019年11月1日 · In normal lung, DDR1 is expressed in bronchiolar epithelial cells as well as in type 1 and 2 alveolar pneumocytes. In IPF, DDR1 retains the same expression patterns in …
DDR1 activation in macrophage promotes IPF by regulating …
2022年12月1日 · DDR1 exacerbate IPF through mediating inflammasome synthesis, assembly and activation in bleomycin-induced IPF models. C57BL/6 mice were induced to IPF models …
DDR1 role in fibrosis and its pharmacological targeting
The present review article focuses on: a) detailing the evidence for a role of DDR1 as an anti-fibrotic target in different organs, b) clarifying DDR1 tissue distribution in healthy and diseased …
Macrophage Implication in IPF: Updates on Immune, Epigenetic, …
As collagen deposition represents a key feature in fibrosis, the receptor tyrosine kinase Discoidin Domain Receptor1 (DDR1), which interacts and gets activated by collagens, was studied in …
Virtual screening for potential discoidin domain receptor 1 (DDR1 ...
2022年11月2日 · Among them, Cpd2, Cpd17, and Cpd18 showed improved binding characteristics, indicating that they may be potential DDR1 inhibitors. In this research, we …
巨噬细胞 DDR1 激活通过调节 NLRP3 炎性体和巨噬细胞反应促进 IPF…
本研究建立了博来霉素诱导的 ipf 小鼠模型，并在体内给予两种 ddr1 抑制剂，以研究 ddr1 在 ipf 中的作用。 慢病毒介导的 DDR1 -/- 稳定的 Raw264.7 巨噬细胞系或 DDR1 抑制剂体外处理，以 …