Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1 …
We identify a 14-3-3-Beclin-1-Akt1 protein complex assembling with DDR1 to be required for prosurvival Akt and mTOR signaling and regulation of autophagy-associated therapy …
盘状结构域受体DDR1：一种新型RTKs成员，肿瘤治疗潜力靶标！
2022年8月1日 · 研究表明，在人乳腺癌和结肠癌中，DDR1主要是通过激活Ras/Raf/ERK和 PI3K/Akt 通路，从而上调抗凋亡蛋白 Bcl-xL 和使得细胞在基因毒性应激状态下存活下来 [5, 16 …
Discoidin domain receptor 1 as a potent therapeutic target in solid ...
2024年9月1日 · Discoidin domain receptor 1 (DDR1) has a significant role in crucial cell survival processes. Upon collagen binding, autophosphorylation of its kinase domain leads to …
Multifaceted collagen-DDR1 signaling in cancer - Cell Press
2023年9月12日 · Discoidin domain receptor 1 (DDR1) is a key sensor of COL fiber state and composition that controls tumor cell metabolism and growth, response to therapy, and patient …
Here, we reveal a critical function of the promitotic and adhesion-mediating discoidin domain receptor 1 (DDR1) in modulating GBM therapy resistance. In GBM cultures and clinical …
A pan-cancer analysis of DDR1 in prognostic signature and tumor ...
2023年4月8日 · DDR1 promoted development in orthotopic glioblastoma mouse models and human ER-positive, HER2-negative breast cancer and reduced the efficacy of chemotherapy …
Discoidin domain receptor 1 promotes lung adenocarcinoma
Our findings uncovered that a high abundance of DDR1 increased the migration and invasion capability of LUAD cells via the AKT/Snail signaling axis and indicated that DDR1 could be a …
A network map of discoidin domain receptor 1 (DDR1)-mediated …
2022年12月1日 · DDR1 activates through the collagen I, IV, IGF-1/IGF1R, and IGF2/IR, regulating downstream signaling molecules such as MAPKs, PI3K/Akt, and NF-kB in diseases. Despite …
Transmembrane-4 L-six family member-1 (TM4SF1) promotes non …
2019年5月29日 · We further found that TM4SF1 exerts these effects in part by regulating the expression of the discoidin domain receptor DDR1 and its downstream target, the …
盘状结构域受体DDR1：一种新型RTKs成员，肿瘤治疗潜力靶标！
研究表明，在人乳腺癌和结肠癌中，DDR1主要是通过激活Ras/Raf/ERK和 PI3K/Akt 通路，从而上调抗凋亡蛋白 Bcl-xL 和使得细胞在基因毒性应激状态下存活下来 [5, 16-17]。