DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C-type lectin expressed by dendritic cells. Dendritic cells are potent antigen-presenting cells capable of activating T-lymphocytes.

The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years, ...

DC-SIGN is a prototype C-type lectin organized in microdomains, which have their role as pathogen recognition receptors in sensing microbes. Although the integrin LFA-1 is a counter-receptor for both ICAM-2 and ICAM-3 on DC, DC-SIGN is …

DC-SIGN recognizes carbohydrates including high mannose glycans and fucose-containing glycans such as Lewis A, Lewis B, Lewis X and Lewis Y or fucosylated LacdiNAc (LDNF) that can be found on its ligands.

DC-SIGN mediates rapid internalization of intact HIV into a low pH non-lysosomal compartment, and the internalized virus retains competence to infect target cells. Removal of the DC-SIGN cytoplasmic tail reduces viral uptake and abrogates the trans-enhancement of T-cell infection.

2003年9月1日 · Dendritic cells (DCs) express Toll-like receptors (TLRs) and C-type lectins that interact with pathogens. C-type lectins interact with specific carbohydrate structures on pathogens to...

2000年3月3日 · A new DC-restricted molecule, DC-SIGN, demystifies two of this cell's contrasting functions: stimulating T lymphocytes to develop immunity, and enhancing HIV-1 and SIV replication. For immunity, it is implied that DC-SIGN allows …

2000年3月3日 · We discovered that instead of the common ICAM-3 receptors LFA-1 and αDβ2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo, mediates transient adhesion with T cells.

2016年3月17日 · DC-SIGN modulates intracellular signaling pathways. DC-SIGN is unable to induce gene expression on its own, but DC-SIGN signaling greatly affects signaling pathways induced by other receptors with a decisive outcome on adaptive immune responses.

2013年4月22日 · DC-SIGN is a multifunctional C-type lectin receptor on antigen-presenting cells. Its functions include adhesion, migration, signaling, and antigen uptake/presentation. All evidence supporting DC-SIGN functions is based on in vitro assays. The absence of a functional DC-SIGN ortholog hampers the study of its physiological role.