D2HGDH Gene - GeneCards | D2HDH Protein | D2HDH Antibody
2025年3月28日 · D2HGDH (D-2-Hydroxyglutarate Dehydrogenase) is a Protein Coding gene. Diseases associated with D2HGDH include D-2-Hydroxyglutaric Aciduria 1 and D-2 …
D2HGDH - Wikipedia
This gene encodes D-2hydroxyglutarate dehydrogenase is a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active …
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase ... - Nature
2015年7月16日 · Here we show that wild-type D2HGDH elevates α-KG levels, influencing histone and DNA methylation, and HIF1α hydroxylation. Conversely, the D2HGDH mutants that we …
d-2-Hydroxyglutarate 是一种抗炎免疫代谢物，在 TLR4 激活后的 …
HOT 将 αKG 和 γ-羟基丁酸相互转化为 D-2HG 和琥珀酸半醛，我们在此确定这种酶在巨噬细胞活化过程中具有免疫反应性和调节性。 D-2HG 的积累可以通过 D-2HG脱氢酶的表达减少来进一 …
Structure, substrate specificity, and catalytic mechanism of …
2021年1月12日 · D-2-hydroxyglutarate dehydrogenase (D-2-HGDH) catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) into 2-oxoglutarate, and genetic D-2-HGDH deficiency leads...
D2HGDH D-2-hydroxyglutarate dehydrogenase [ (human)]
2025年2月8日 · Gene ID: 728294, updated on 8-Feb-2025. This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding …
D2HGDH D-2-hydroxyglutarate dehydrogenase - NIH Genetic …
2023年11月23日 · Clinical resource with information about D2HGDH, D-2-hydroxyglutaric aciduria 1, and available tests. There are links to practice guidelines and authoritative resources like …
D-2-羟基戊二酸脱氢酶（D2HGDH）基因 | MCE
该基因编码 D-2 羟基戊二酸脱氢酶，一种属于 FAD 结合氧化还原酶/转移酶 4 型家族的线粒体酶。 这种酶在肝脏和肾脏中最活跃，但在心脏和大脑中也很活跃，可将 D-2-羟基戊二酸转化为 2- …
D2HGDH-mediated D2HG catabolism enhances the anti-tumor
2022年3月2日 · D2HGDH is an inducible enzyme that converts D2HG into the endogenous metabolite 2-oxoglutarate. We aimed to evaluate the impairment of CD8 T lymphocyte function …
D2HGDH gene: MedlinePlus Genetics
The D2HGDH gene provides instructions for making an enzyme called D-2-hydroxyglutarate dehydrogenase. This enzyme is found in mitochondria, which are the energy-producing …