Our results demonstrate that PB-mediated engineering of ARPE-19 is an efficient way to generate hormone secreting cell lines compatible with macroencapsulation, and our CMV-driven expression cassette allows for identification of clones with high level and long-term secretory activity without addition of insulator elements.

2021年6月18日 · Growth hormone (GH) and its mediator insulin-like growth factor-1 (IGF-1) have manifold effects on the kidneys. GH and IGF receptors are abundantly expressed in the kidney, including the glomerular and tubular cells.

2023年6月6日 · Here, we show GHRH-R is an important regulator of Th17 cell differentiation in Th17 cell-mediated ocular and neural inflammation. We find that GHRH-R is not expressed in naïve CD4 + T cells, while...

Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1). The GH/IGF1 system plays a key role in normal kidney development, glomerular ...

2019年2月8日 · Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for normal postnatal growth and has pleiotropic effects across multiple...

1986年9月1日 · Binding of human GH (hGH) and insulin-like growth factors I and II (IGFI and II) to isolated human adipocytes from adult subjects was studied. Binding equilibrium for hGH at 24°C was reached at 120 min and half-maximal specific binding at 6–8 ng ml. Apparent Ka was 2.1 × 10 9 M −1 and Bmax 7.3 × 10 −11 M/10 6 cells.

Growth hormone (GH), secreted by the somatotropes in the anterior part of pituitary gland, is the predominant hormone that regulates linear growth. Its production and secretion are controlled by growth hormone-releasing hormone (GHRH), along with the somatostatin, GH itself, and downstream factors such as insulin growth factor 1 (IGF-1).

1992年9月1日 · Growth hormone secretion by the pituitary gland is dependent on the dual regulation exerted by growth hormone-releasing hormone and somatostatin, which are the final integrative pathways for several signals reaching the hypothalamus. Regulatory signals include neurotransmitters, neuropeptides, and peripheral signals such as hormones or nutrients.

Growth hormone (GH) increases lean body mass, reduces fat mass, increases exercise tolerance and maximum oxygen uptake, enhances muscle strength, and improves linear growth. Long-term studies of GH administration offer conflicting results regarding its safety, which has led to strict FDA criteria for GH use.

2025年2月5日 · Growth hormone (GH) is a key polypeptide hormone secreted by somatotroph cells in the anterior pituitary gland, essential for postnatal growth, metabolism, and systemic homeostasis. Its secretion is regulated by hypothalamic neuropeptides, including GH-releasing hormone and somatostatin.