2023年8月29日 · Efforts to translate these findings to humans are being pursued by a start-up company Cyta Therapeutics, which was founded at the UMass Institute for Applied Life Sciences (IALS) based on the nanogel technologies from the Thayumanavan lab.

Cyta is building a pipeline of products based on a novel class of polymer-based nanogels, called IntelliGels. The company’s lead development program is a therapeutic (Cyta-001) to treat …

2023年11月6日 · Scientists have developed a nanogel-based delivery system that successfully targets and reverses obesity in mice by delivering drugs directly to the liver, avoiding side effects and enhancing drug efficacy. The startup company Cyta Therapeutics is working to translate these findings for human use.

2023年8月29日 · Efforts to translate these findings to humans are being pursued by a start-up company Cyta Therapeutics, which was founded at the UMass Institute for Applied Life Sciences (IALS) based on the...

2023年9月5日 · Efforts to translate these findings to humans are being pursued by a start-up company Cyta Therapeutics, which was founded at IALS. The company’s lead product, Cyta …

Efforts to translate these findings to humans are being pursued by a start-up company Cyta Therapeutics, which was founded at the UMass Institute for Applied Life Sciences (IALS) based on the nanogel technologies from the Thayumanavan lab.

网络药理学显示 CYTA 可以调节氧化应激、细胞凋亡和钙信号传导。 细胞实验表明，CYTA 可降低 CK、LDH 和 MDA 的水平，以及 ROS 的产生和 Ca2+ 浓度。 此外，CYTA 改善细胞凋亡并增加 SOD 、 CAT 和 GSH-Px 的活性，以及 ATP 和 Ca2+-ATP 酶含量和线粒体膜电位的水平。

Increased safety: no systemic exposure of thyromimetic IP filed – IntelliGel + TRβ agonist TRβ agonist CYTA-001 Stimulus-dependent intracellular payload release in the liver Initiating Agent Reducing Agent (THF, 65° C) (DTT) + drug + liver targeting moiety

这项工作研究了氯化钙 (CaCl 2 ) 作为钠替代物对鲢鱼鱼糜理化性质的影响。 当NaCl被0.32%和0.63% CaCl 2 替代时，鱼糜凝胶表现出更好的质地性能、断裂力和流变性能，而0.95%、1.27%和1.58% CaCl 2 导致凝胶强度变差。 随着CaCl 2 的加入，持水能力（WHC）显着降低（p < .05）， T 23 弛豫时间减少， T 23 的比例增加。 与对照相比，0.63% CaCl 2 的 鱼糜凝胶中巯基含量 增加了 23.61%，溶解度下降了 17.31%。 此外，拉曼光谱数据表明，在用 CaCl 2 制备 …

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