Cytochrome c is a peripheral protein of the mitochondrial inner membrane and functions as an electron shuttle between complex III and complex IV of the respiratory chain and its activity is necessary for life.

Cytc is an evolutionarily conserved nuclear-encoded mitochondrial protein, which contains 104 amino acids in mammals. It is highly positively charged with a pI of 9.6. Cytc is essential for aerobic energy production and Cytc knockout mice die around midgestation (Li et al., 2000a).

2006年5月5日 · Cyt c, a peripheral protein of the mitochondrial inner membrane (IM), functions as an electron shuttle between complex III and complex IV of the respiratory chain and its activity is...

Cytochrome c is an important component of the Electron Transport Chain for the synthesis of ATP (Figure 2). Cytochrome c is a water soluble electron transport protein that is loosely associated with the mitochondrial inner membrane.

Cytochrome c, or cyt c is a small, water soluble heme protein associated with the inner membrane of the mitochondrion. It is an essential link in the electron transport chain through which cells perform the controlled "burning" of glucose and capture much of that released energy by storing it in ATP , the cell's primary energy distribution ...

Cytochrome c is a well-known mitochondrial protein that fulfills life-supporting functions by transferring electrons to the respiratory chain to maintain ATP production. However, during the activation of apoptotic machinery, it is released from ...

2024年3月23日 · We summarize how posttranslational modifications of cytochrome c (e.g., phosphorylation, acetylation, tyrosine nitration, and oxidation), binding proteins (e.g., HIGD1A, CHCHD2, ITPR1, and...

Cytochrome c (cyt c) is an electron transporter of the mitochondrial respiratory chain. Upon permeabilization of the mitochondrial outer membrane, cyt c is released into the cytoplasm, where it triggers the intrinsic pathway of apoptosis. ...

2016年1月26日 · Here, we unify the knowledge of the structural flexibility of cyt c that supports functional moonlighting and review biochemical and immunochemical evidence confirming that cyt c undergoes conformational changes during normal and altered cellular homeostasis.

2020年4月1日 · Proposed pivotal role of Cytc in respiration and apoptosis. Cytc acts as an electron carrier between complex III (bc 1 complex) and complex IV (cytochrome c oxidase) in the ETC resulting in efficient ATP production at complex V (ATP synthase).