CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of the two primary bile acids, cholic acid and chenodeoxycholic acid, both of which are secreted in the bile.

cyp8b1是ca合成关键酶，它决定了非12-oh bas（cdca，α/β-mca，udca，lca, hca, hdca及其他替代途径的衍生物）与12-oh bas（ca，dca）的比例。 最近研究表明，cyp8b1耗竭或下调引起12-oh ba水平减少，从而增加了非-12-oh / 12-oh ba的比例，对宿主代谢状态产生有益影响。

2025年3月28日 · CYP8B1 (Cytochrome P450 Family 8 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP8B1 include Intrahepatic Cholestasis Of Pregnancy and Extrahepatic Cholestasis. Among its related pathways are Oxidation by cytochrome P450 and Bile acid and bile salt metabolism.

细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。 这种内质网膜蛋白催化 7-alpha-hydroxy-4-cholesten-3-one 转化为 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one。 这两种类固醇之间的平衡决定了胆酸和鹅脱氧胆酸的相对量，这两种物质都分泌到胆汁中并影响胆固醇的溶解度。 该基因在细胞色素 P450 基因中是独一无二的，因为它是无内含子的。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the …

2025年2月19日 · RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels. Title: Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis.

2022年9月1日 · Cytochrome P450 8B1 (CYP8B1), which synthesizes CA, was induced in livers of colitic mice. CA-treated or liver Cyp8b1-overexpressing mice developed more severe colitis with compromised repair of the mucosal barrier, whereas Cyp8b1-knockout mice were resistant to …

2025年1月31日 · Enrichment of A. muciniphila leads to generate more indole-3-lactic acid (ILA) to upregulate the expression of 12α-hydroxylase (CYP8B1) via fat mass and obesity-associated protein (FTO)/ N6 -methyladenosine (m 6 A)/YTHDF2 manner, thereby facilitating cholesterol converts to cholic acid (CA).

Here, we demonstrated that the hepatic CYP8B1-CA pathway dampened Lgr5 + ISC regeneration by repression of peroxisome proliferator-activated receptor alpha (PPARα)-dependent fatty acid oxidation (FAO), and ultimately promoted colitis, thus uncovering the functional importance of the BA-based liver-gut axis during colitis pathogenesis.

2022年9月4日 · 进一步采用特异性敲除肠Ppara的小鼠，研究人员证实了CYP8B1-CA代谢轴通过抑制PPARα介导的FAO过程，阻碍Lgr5+ISCs的更新，加重IBD状态下的肠道屏障损伤。 图一.

2023年10月11日 · CYP8B1 is a critical downstream target of VSG. Modulation of BA composition and gut microbiota profile by targeting CYP8B1 may provide novel insight into the development of therapies that noninvasively mimic bariatric surgery to treat obesity and its complications.