2025年3月30日 · CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP26A1 include Embryonal Carcinoma and Acute Promyelocytic Leukemia. Among its related pathways are Oxidation by cytochrome P450 and Signaling by Retinoic Acid.

Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene. [5][6][7] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

这种内质网蛋白作用于类视黄醇，包括全反式视黄酸 (RA) ，具有 4-羟基化和 18-羟基化活性。 这种酶调节视黄酸的细胞水平，视黄酸参与胚胎和成人组织中基因表达的调节。 已经报道了该基因的两种选择性剪接的转录物变体，它们编码不同的同种型。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the Cytochrome P450 superfamily of Enzymes.

The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA) metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 family enzymes, CYP26A1, CYP26B1 and CYP26C1 have all been shown to metabolize all-trans-retinoic acid (atRA) it's 9-cisRA and 13-cisRA isom …

CYP26A1 is expressed in human liver microsomes; its expression correlates with retinoic acid hydroxylation. cytochrome P450 family 26 (CYP26) enzymes have a role in determining the cellular exposure to retinoic acid by inactivating retinoic acid in cells that do not need retinoic acid- …

This manuscript reports the discovery of a mechanism that links two major cellular pathways, retinoic acid (RA) and WNT signaling, which are involved in colorectal cancer (CRC) development. The link between the two pathways is CYP26A1 enzyme, which ...

All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have biologic …

As a first step in understanding the developmental function of RA-metabolizing enzymes, we have disrupted the murine Cyp26A1 gene. We report that Cyp26A1 -null mutants die during mid-late gestation and show a number of major morphogenetic defects.

细胞色素 P450 酶 CYP26 被认为通过氧化代谢部分调节 atRA 的细胞浓度，从而影响类视色素稳态和信号传导。 CYP26A1 和 CYP26B1 是 atRA 羟化酶，可催化细胞系统中类似代谢物的形成。 然而，它们只有 40% 的序列相似性，表明这两种酶之间存在差异。 本研究的目的是确定 CYP26A1 和 CYP26B1 是否具有相似的催化活性、从 atRA 形成不同的代谢物并在成人的不同组织中表达。 CYP26A1 和 CYP26B1 的 mRNA 表达与人体组织之间存在相关性，除了人小脑中 CYP26B1 …

2024年3月5日 · Clinical resource with information about CYP26A1, Biological, clinical and population relevance of 95 loci for blood lipids., Discovery and refinement of loci associated with lipid levels., Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia., and available tests.