Cyclins are generally very different from each other in primary structure, or amino acid sequence. However, all members of the cyclin family are similar in 100 amino acids that make up the cyclin box. Cyclins contain two domains of a similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are ...

2023年7月19日 · The cell cycle is regulated by cyclins, a type of protein that binds and activates cyclin dependent kinases (CDKs).

Cyclin F plays a role in cell cycle regulation through selective ubiquitination or binding of cell cycle proteins. • Cyclin F is involved in DNA synthesis and repair mechanisms, important in the context of genotoxic stress. • Cyclin F dysfunction has been linked to cancer, amyotrophic lateral sclerosis and frontotemporal dementia.

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis. The kinases are organized in a pathway to ensure that, during cell division, each cell ...

Different cyclin-CDK complexes regulate different phases of the cell cycle, known as G0/G1, S, G2, and M phases, featuring several checkpoints to maintain genomic stability and ensure accurate DNA replication. [1] [5] Cyclin-CDK complexes of earlier cell-cycle phase help activate cyclin-CDK complexes in later phase. [4]

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition. Cyclin D protein is anywhere from 155 (in zebra mussel) to …

Cyclins control cell cycle progression by regulating the activity of cyclin-dependent kinases (Cdks). Cyclin I is a member of the cyclin family because of the presence of a cyclin box motif. It has been suggested that Cyclin I is involved in various ...

Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis.

2025年1月13日 · Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division. In reality, the human genome contains 20 different CDKs, which can be divided in at least three different sub-family with differ …

1999年5月14日 · It is now widely understood that cyclin/Cdks work hand-in-hand with ubiquitin-mediated proteolysis to provide the logical framework for cell cycle regulation. Not only are the levels of cyclins regulated by ubiquitination, but so are the levels of a …